Acute hemorrhagic edema of infancy and common mimics

The American Journal of Emergency Medicine
James L Homme, Jason M Block

Abstract

Acute hemorrhagic edema of infancy (AHEI) is a rare acute benign cutaneous leukocytoclastic vasculitis affecting children younger than 24 months of age. Its presentation can be confused with those of urticaria, erythema multiforme, Henoch-Schönlein purpura, idiopathic thrombocytopenia,meningococcemia, Kawasaki disease, and drug rash. We present 2 cases of acute hemorrhagic edema of infancy, discuss the characteristics of AHEI, and compare and contrast AHEI with similar dermatologic presentations. This review provides emergency physicians with the basic knowledge necessary to easily recognize AHEI as a distinct clinical entity. The patients were 19- and 23-month-old females who presented to the pediatric emergency department at St Mary's Hospital,Mayo Clinic in Rochester, Minnesota, with impressive purpuric rashes and edema of the hands and feet after preceding upper respiratory tract infections. Both children had benign courses with complete resolution of clinical findings. These 2 cases typify the presentation of AHEI.Acute hemorrhagic edema of infancy presents with characteristic purpuric lesions and extremity edema. The emergency physician's recognition of these presenting characteristics will help diagnose AHEI, avoid unnec...Continue Reading

References

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Citations

Nov 1, 2016·Clinical Pediatrics·Elisavet EfstathiouAdamos Hadjipanayis
Mar 9, 2019·International Journal of Environmental Research and Public Health·Francesco MiconiSusanna Esposito
Mar 1, 2017·Case Reports in Pediatrics·Hannah ChesserEric Zwemer
Nov 4, 2020·BMJ Case Reports·Ugo CucinottaRomina Gallizzi
Sep 14, 2020·The American Journal of Emergency Medicine·Elie SalibaZeina Tannous
Mar 12, 2021·Italian Journal of Pediatrics·Sarah ContornoAndrea Taddio
Aug 17, 2018·Pediatric Emergency Care·Carolina VegaHenry P Chicaiza

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