PMID: 15371928Sep 17, 2004Paper

Acute hepatitis due to buprenorphine administration

European Journal of Gastroenterology & Hepatology
Sophie HervéEric Lerebours

Abstract

Buprenorphine, a synthetic molecule derived from thebaine, has been commercialized in France since 1987 as a substitute treatment for pharmacodependence on opiates. Hepatotoxicity is poorly documented, since only few cases of hepatic injury have been reported. We report seven cases of acute cytolytic hepatitis due to buprenorphine. All patients were former drug addicts by the parenteral route and had been receiving withdrawal therapy with buprenorphine for an average of 91 days at a daily dosage ranging from 2 to 12 mg. Liver tests, complete viral screening and an abdominal computerized tomography scan were performed in each patient. Five out of seven subjects presented with acute icteric hepatitis without abdominal pain or fever. Average alanine aminotransferase levels were 39 times the normal rate. There was no sign of liver failure. All patients had anti-hepatitis C virus-positive serology and two had positive hepatitis C virus-RNA. Although no specific treatment was administered, buprenorphine doses were reduced whenever possible. Cytolysis and jaundice resolved rapidly in all cases, although treatment was continued at the same doses in four cases and the dosage was reduced by 50% in three other cases. Although buprenorphin...Continue Reading

References

Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PuotiE Cariani
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Sep 1, 1994·The Journal of Cell Biology·M SomasundaranR H Singer
May 1, 1994·Clinical Pharmacology and Therapeutics·S L WalshG E Bigelow
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·J R UngoA E Pitchenik
Aug 27, 1998·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·G CorraoP Torchio
May 16, 2000·Cell Biology and Toxicology·D PessayreB Fromenty
Apr 3, 2001·Journal of Hepatology·A BersonD Pessayre
Apr 9, 2001·Clinics in Liver Disease·J H Lewis, H J Zimmerman

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Citations

Nov 9, 2006·Current HIV/AIDS Reports·Paula J Lum, Jacqueline Peterson Tulsky
Jul 23, 2010·Journal of Psychoactive Drugs·Donald R Wesson, David E Smith
Nov 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lynn E SullivanDavid A Fiellin
Dec 29, 2010·Journal of Child and Adolescent Psychopharmacology·Anu Upadhyay, Ye Xueming
Apr 9, 2005·Current Opinion in Gastroenterology·Susan K LazerowJames H Lewis
Dec 21, 2010·Journal of Addiction Medicine·Michael P BogenschutzGeorge E Woody
Mar 1, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·David A FiellinUNKNOWN BHIVES Collaborative
Dec 10, 2014·The American Journal of Drug and Alcohol Abuse·Arzu Ciftci DemirciAyten Erdogan
Oct 29, 2011·Clinics in Liver Disease·Andrea DiMartiniMary Amanda Dew
Feb 26, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M ZuinM Podda
Feb 17, 2015·Journal of Biochemical and Molecular Toxicology·Saeed SamarghandianFatemeh Karimnezhad
Aug 28, 2012·Drug and Alcohol Dependence·Andrew J SaxonPetra Jacobs
Mar 1, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pamela Vergara-RodriguezUNKNOWN BHIVES Collaborative
Sep 16, 2014·Journal of Addiction Medicine·Michelle R Lofwall, Sharon L Walsh

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