PMID: 8583080Sep 1, 1995Paper

Acute hepatotoxicity from ingestion of yellow phosphorus-containing fireworks

Journal of Clinical Gastroenterology
O U Fernandez, L L Canizares

Abstract

We reviewed 15 cases of poisoning from ingestion of yellow phosphorus-containing fireworks and analyzed its associated acute hepatotoxic effects. Two patients (13%) had no clinical or biochemical evidence of hepatic damage, four (27%) had subclinical hepatic injury, five (33%) manifested varying degrees of hepatocellular necrosis and cholestasis, and four (27%) had fulminant hepatic failure. Jaundice was not associated with mortality (p > 0.05), but it appeared to predict the length of hospital confinement. Early elevations in transaminase and alkaline phosphatase, a more than tenfold increase in alanine aminotransferase, and a severe derangement in prothrombin time all indicate poor prognosis. Metabolic acidosis and hypoglycemia were significantly associated with mortality (p < 0.01 and p < 0.05, respectively). The use of intravenous N-acetylcysteine did not significantly alter disease outcome (p > 0.05). Our mortality rate was 27%, confirming that yellow phosphorus is extremely lethal when ingested. Its indiscriminate use in the manufacture of fireworks should be eliminated.

Citations

Feb 11, 2010·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Abdurrahim SayilirNurgul Sasmaz
Jun 30, 2011·Indian Journal of Pharmacology·Anupama MauskarPreeti Shanbag
Feb 21, 2014·Journal of Pharmacology & Pharmacotherapeutics·C P LakshmiDebdatta Basu
Feb 4, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Fabricio González-Andrade, Ramiro López-Pulles
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Feb 6, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Carol D'Silva, Bhuvana Krishna

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