Acute high intensity interval exercise reduces colon cancer cell growth

The Journal of Physiology
James L DevinTina L Skinner

Abstract

Physical activity is associated with reduced mortality rates for survivors of colorectal cancer. Acute high intensity interval exercise (HIIE) reduced colon cancer cell number in vitro and promoted increases in inflammatory cytokines immediately following exercise. This acute suppression of colon cancer cell number was transient and not observed at 120 minutes post-acute HIIE. The acute effects of exercise may constitute an important mechanism by which exercise can influence colorectal cancer outcomes. Physical activity is associated with significant reductions in colorectal cancer mortality. However, the mechanisms by which exercise mediates this anti-oncogenic effect are not clear. In the present study, colorectal cancer survivors completed acute (n = 10) or chronic (n = 10) exercise regimes. An acute high intensity interval exercise session (HIIE; 4 × 4 min at 85-95% peak heart rate) was completed with serum samples collected at baseline, as well as 0 and 120 min post-exercise. For the 'chronic' intervention, resting serum was sampled before and after 4 weeks (12 sessions) of HIIE. The effect of serum on colon cancer cell growth was evaluated by incubating cells (CaCo-2 and LoVo) for up to 72 h and assessing cell number. Ser...Continue Reading

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Citations

Jun 19, 2019·The Journal of Physiology·Veridiana Mota MoreiraPaulo Cezar de Freitas Mathias
Aug 1, 2019·European Journal of Clinical Nutrition·Naomi Fliss-IsakovShira Zelber-Sagi
Apr 4, 2021·Sports·Polyxeni SpiliopoulouGerasimos Terzis
Apr 18, 2021·European Journal of Applied Physiology·Richard S MetcalfeSamuel T Orange
Jun 24, 2021·Nature Reviews. Urology·Jin-Soo KimDennis R Taaffe
Jul 20, 2021·Sports Medicine - Open·Catherine F S MarriottRobert J Petrella
Aug 31, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Michael A Chapek, Robert G Martindale
Sep 25, 2021·Medicine and Science in Sports and Exercise·Jin-Soo KimRobert U Newton

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