Acute high-intensity interval running increases markers of gastrointestinal damage and permeability but not gastrointestinal symptoms

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Jamie N PughGraeme L Close

Abstract

The purpose of this study was to investigate the effects of high-intensity interval running on markers of gastrointestinal (GI) damage and permeability alongside subjective symptoms of GI discomfort. Eleven male runners completed an acute bout of high-intensity interval training (HIIT) (eighteen 400-m runs at 120% maximal oxygen uptake) where markers of GI permeability, intestinal damage, and GI discomfort symptoms were assessed and compared with resting conditions. Compared with rest, HIIT significantly increased serum lactulose/rhamnose ratio (0.051 ± 0.016 vs. 0.031 ± 0.021, p = 0.0047; 95% confidence interval (CI) = 0.006 to 0.036) and sucrose concentrations (0.388 ± 0.217 vs. 0.137 ± 0.148 mg·L-1; p < 0.001; 95% CI = 0.152 to 0.350). In contrast, urinary lactulose/rhamnose (0.032 ± 0.005 vs. 0.030 ± 0.005; p = 0.3; 95% CI = -0.012 to 0.009) or sucrose concentrations (0.169% ± 0.168% vs. 0.123% ± 0.120%; p = 0.54; 95% CI = -0.199 to 0.108) did not differ between HIIT and resting conditions. Plasma intestinal-fatty acid binding protein (I-FABP) was significantly increased (p < 0.001) during and in the recovery period from HIIT whereas no changes were observed during rest. Mild symptoms of GI discomfort were reported immediat...Continue Reading

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Citations

Jan 19, 2019·PloS One·Łukasz TotaWanda Pilch
Jun 9, 2019·European Journal of Applied Physiology·John O OsborneGeoffrey M Minett
Oct 1, 2019·European Journal of Applied Physiology·John O OsborneGeoffrey M Minett
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Feb 19, 2020·American Journal of Physiology. Endocrinology and Metabolism·Jamie N PughGraeme L Close
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Jun 17, 2021·European Journal of Applied Physiology·Kyle A SmithMichael J Ormsbee
Mar 17, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kate H EdwardsCecilia M Kitic

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