PMID: 6111018Apr 1, 1981Paper

Acute hormonal effects on carnitine metabolism in thin and obese subjects: responses to somatostatin, glucagon, and insulin

Metabolism: Clinical and Experimental
S M Genuth, C L Hoppel

Abstract

Plasma free carnitine and acylcarnitines were determined in man during acutely induced insulin deficiency. A 5-hr infusion of somatostatin at 6 microgram/min in 10 thin subjects produced profound, sustained hypoinsulinemia and led to rapid increases in plasma free fatty acids and ketoacids (peak increments of 0.67 mM each). Simultaneously, plasma free carnitine decreased, while plasma long-chain and short-chain acylcarnitines increased significantly. When hyperglucagonemia was created by inclusion of glucagon with the somatostatin, the hyperketonemia was reversed after 2 hr and the increase in acylcarnitine abolished. However, the decrease in free carnitine was accentuated. The antiketogenic effect of adding glucagon was due to an eventual breakthrough of the somatostatin blockade on insulin secretion, the latter gradually returning toward preinfusion levels. Inclusion of exogenous insulin with the somatostatin-glucagon infusion immediately lowered free fatty acids and ketoacids. Acylcarnitines also declined promptly, while the accelerated fall in free carnitine produced by glucagon was blunted by the addition of insulin. Qualitatively and quantitatively comparable results were seen in seven obese subjects. This study suggests:...Continue Reading

References

Dec 1, 1979·Diabetes·S M Genuth, C L Hoppel
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Citations

May 1, 1988·European Journal of Pediatrics·E Schmidt-SommerfeldD Penn
Jul 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·C RössleP Fürst
Jan 1, 1996·Life Sciences·S Krähenbühl
Nov 27, 2015·Journal of Immunological Methods·Rabab M Abou El-MagdDavid S Wishart
Oct 1, 1982·Biochemical Medicine·K J Valkner, L L Bieber
Feb 1, 2006·Diabetes Research and Clinical Practice·Signorelli Salvatore SantoAnzaldi Massimiliano
Mar 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A D'ArienzoG Mazzacca
Feb 1, 1988·Biochemical Medicine and Metabolic Biology·D J PaulsonA L Shug
May 28, 2020·American Journal of Physiology. Endocrinology and Metabolism·Michael L BlackburnSean H Adams
Jul 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R K Fuller, C L Hoppel

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