Acute hyperfibrinogenemia impairs cochlear blood flow and hearing function in guinea pigs in vivo

International Journal of Audiology
Fritz IhlerMartin Canis

Abstract

Impairment of microcirculation is a possible cause of sudden sensorineural hearing loss (SSNHL). Fibrinogen is known as a risk factor for both microvascular dysfunction and SSNHL. Therefore, the aim of this study was to investigate the effect of elevated serum levels of fibrinogen on cochlear blood flow and hearing function in vivo. One group of guinea pigs received two consecutive injections of 100 mg fibrinogen while a control group received equimolar doses of albumin. Measurements of cochlear microcirculation by intravital microscopy and of hearing thresholds by auditory brainstem response (ABR) recordings were carried out before, after first and after second injection. Ten healthy guinea pigs were randomly assigned to a treatment group or a control group of five animals each. Serum fibrinogen levels were elevated after the first and second injections of fibrinogen compared to basal values and control group respectively. Increasing levels of fibrinogen were paralleled by decreasing cochlear blood flow as well as increasing hearing thresholds. Hearing threshold correlated negatively with cochlear blood flow. The effect of microcirculatory impairment on hearing function could be explained by a malfunction of the cochlear ampli...Continue Reading

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Citations

Jul 17, 2014·BMC Ear, Nose, and Throat Disorders·Julia WittigOrlando Guntinas-Lichius
Nov 18, 2015·Acta Oto-laryngologica·Ryohei OyaHidenori Inohara
Apr 18, 2015·BioMed Research International·Friedrich IhlerMartin Canis
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Nov 15, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Mattis BertlichMartin Canis
Oct 12, 2018·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Ryohei OyaHidenori Inohara
Jul 26, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Mattis BertlichMartin Canis
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Jan 28, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Friedrich IhlerMattis Bertlich
Feb 26, 2021·The Journal of International Medical Research·Yi QianJihong Zeng
Jul 17, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Bernhard G WeissMattis Bertlich

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