Acute hyperglycemia and hyperinsulinemia enhance adrenergic vasoconstriction and decrease calcitonin gene-related peptide-containing nerve-mediated vasodilation in pithed rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Yoshito ZamamiHiromu Kawasaki

Abstract

Recent clinical studies have demonstrated that transient postprandial hyperglycemia and hyperinsulinemia may contribute to the development of hypertension. Therefore, we investigated the influence of acute hyperglycemia and/or hyperinsulinemia induced by glucose or insulin infusion on neuronal and humoral control of vascular tone in rats. Euglycemic male Wistar rats were pithed under anesthesia and arterial blood pressure was measured. Changes in vascular responses to spinal cord stimulation (SCS) and intravenous bolus injections of noradrenaline, angiotensin II, calcitonin gene-related peptide (CGRP), acetylcholine and sodium nitroprusside (SNP) were studied by infusing various concentrations of glucose or insulin. Continuous glucose infusion, which increased both blood glucose and serum insulin levels, significantly augmented adrenergic nerve-mediated pressor responses to SCS without affecting pressor responses to injection of noradrenaline or angiotensin II. In pithed rats with artificially increased blood pressure and blockade of autonomic outflow, glucose infusion attenuated CGRPergic nerve-depressor responses to SCS without affecting depressor responses to injection of CGRP, acetylcholine or SNP. In pithed rats treated wi...Continue Reading

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Citations

Jan 16, 2009·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yoshito ZamamiHiromu Kawasaki
Feb 11, 2012·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Shingo TakatoriHiromu Kawasaki
Sep 22, 2009·International Journal of Cardiology·Gabriele FragassoAlberto Margonato
May 16, 2009·Diabetes Research and Clinical Practice·I M PalmerH W Huisman
Mar 26, 2009·Journal of Pineal Research·Silvia Bertuglia, Russel J Reiter
Nov 3, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Shingo Takatori
Sep 30, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Seniz AkcayMahmut Eren
Jan 25, 2017·BioMed Research International·Abimael González-HernándezCarlos M Villalón
Jan 25, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Barry Ting Sheen KwehAndrew Morokoff
Jul 20, 2021·Diabetes Research and Clinical Practice·Alfredo CaturanoFerdinando Carlo Sasso
May 7, 2009·Current Opinion in Neurology
Oct 5, 2011·Pediatrics·Gastón Andrés TopolHung-wen Yeh

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