Abstract
Hypersensitivity reactions to chemotherapy agents are defined as unexpected reactions with signs and symptoms not consistent with known toxicity of these drugs. These reactions range from mild to life-threatening and are difficult to predict. Symptoms include flushing, nausea, difficulty breathing, back pain, hypotension and tachycardia. Hypersensitivity is commonly encountered owing to the increasing use of chemotherapy drugs in clinical practice. The pathogenetic mechanisms are not fully understood but they seem to vary between agents. Reactions to taxanes usually occur during the first few minutes of the first or second infusion, whereas acute reactions to platinum agents usually occur after multiple cycles of therapy. Basic principles that allow management and possible completion of the regimen should be followed. Certain protocols aim to prevent acute reactions by slowing the infusion rate and by administering steroid and histamine receptor antagonists. Skin testing and desensitization protocols have also been successfully used in case of hypersensitivity to various chemotherapy drugs. Knowledge of all available management options assists physicians in making the most appropriate decision regarding further treatment.
Citations
Aug 4, 1992·Biochemical Pharmacology·E ArnaezL M Botana
Mar 7, 1996·European Journal of Pharmacology·E Brzezińska-BłaszczykJ Ochocki
Aug 26, 1999·Seminars in Oncology Nursing·T M Labovich
Jul 1, 2015·Expert Opinion on Investigational Drugs·Stefano BoglioloArsenio Spinillo
Jan 8, 2014·Internal Medicine Journal·J C KuoD Yip
Jun 10, 2015·Japanese Journal of Clinical Oncology·Shingo MiyamotoKazumichi Ando
Apr 29, 2014·Gynecologic Oncology·Sarah E TaylorRobert P Edwards
Nov 2, 2017·Journal of Clinical Pharmacy and Therapeutics·H CapelleM Montana
Sep 25, 2020·Social Work in Public Health·Ameneh JafariZahra Jafari
May 5, 2018·The American Journal of Hospice & Palliative Care·David J BartlettAminah Jatoi
Mar 6, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tingting Sun, Lei Li
Feb 16, 2019·BMC Cancer·Omar F KhanPatricia A Tang
Jan 12, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Dhani WijayaUNKNOWN Suharjono
Sep 22, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Amélie DubromelFlorence Ranchon