Acute hypotensive transfusion reaction with concomitant use of angiotensin-converting enzyme inhibitors: a case report and review of the literature

American Journal of Therapeutics
Ankur KalraDhana R Selvaraj

Abstract

Hypotension can be a manifestation of transfusion reactions, including acute hemolysis, bacterial contamination, transfusion-related acute lung injury, and anaphylaxis. In addition to hypotension, these reactions usually present with other characteristic symptoms and signs. In rare cases, hypotension is the only manifestation of a transfusion reaction. This reaction, characterized by early and abrupt onset of hypotension that resolves quickly once the transfusion is stopped, is referred to as acute hypotensive transfusion reaction (AHTR). We report a case of AHTR observed in a patient on angiotensin-converting enzyme inhibitor therapy. The Naranjo adverse drug reaction probability scale score indicated that the association between angiotensin-converting enzyme inhibitor therapy and AHTR was probable. If a patient on angiotensin-converting enzyme inhibitor therapy develops AHTR, it is important to recognize the need to switch to another class of antihypertensive medication, at least while the patient continues to require transfusion.

References

Jul 13, 1978·The New England Journal of Medicine·B M AlvingJ S Finlayson
Dec 12, 1992·Lancet·A A KroonA F Stalenhoef
Dec 12, 1992·Lancet·D L Mwaniki, S W Guthua
Feb 2, 1999·Clinical Reviews in Allergy & Immunology·A P KaplanM Silverberg
Apr 25, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Cataldo DoriaJay H Herman

❮ Previous
Next ❯

Citations

Jun 11, 2016·Anesthesia and Analgesia·Ryan A MetcalfJennifer Andrews
Mar 4, 2015·Transfusion·Monica B PaganoAaron A R Tobian
Jun 10, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Rajni BassiKusum K Thakur
Jan 27, 2021·Clinics in Laboratory Medicine·Nataliya Sostin, Jeanne E Hendrickson
Jul 13, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M RaturiA Sahrawat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Cataldo DoriaJay H Herman
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
J Lavee, Y Paz
© 2021 Meta ULC. All rights reserved