PMID: 8594006Nov 1, 1995Paper

Acute hypoxic ventilation, carotid body cell division, and dopamine content during early hypoxia in rats

Journal of Applied Physiology
D Bee, D J Pallot

Abstract

In a previous study, we showed that the acute hypoxic ventilatory response was blunted in anesthetized chronically hypoxic rats and was restored by blockade of the dopamine D2 receptor with domperidone. We now report observations made during 1-8 days of exposure to 10% O2 on the acute hypoxic ventilatory response and the effect of domperidone and relate them to dopamine content and cellular proliferation in the carotid body. Hypoxic exposure caused a parallel shift in the hypoxic response curve to higher levels of ventilation and arterial oxygen saturation. The greatest response occurred on day 1 and was unaffected by domperidone: dopamine content diminished and mitotic activity increased. By 8 days, hypoxic ventilation approached normal and was significantly augmented by domperidone; in the carotid body, dopamine levels had risen above the control level and mitoses had diminished. Thus the increase in ventilation was inversely related to carotid body dopamine content, which was depressed. The possibility of a causal relationship is discussed.

Citations

Aug 24, 2000·Journal of Applied Physiology·K A HueyF L Powell
Oct 18, 2002·Microscopy Research and Technique·Zun-Yi Wang, Gerald E Bisgard
Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·Vincent Joseph, Jean-Marc Pequignot
Jun 10, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kouki KatoYoshio Yamamoto
May 11, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·J ChenS Fidone
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V JosephJ M Pequignot
Oct 18, 2002·Microscopy Research and Technique·Estelle B Gauda
Jun 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Delphine Lumbroso, Vincent Joseph
Dec 24, 2005·Journal of Neurocytology·Brian D Gulbransen, Thomas E Finger
Dec 22, 2007·Journal of Applied Physiology·Z-Y WangG E Bisgard
Feb 25, 2000·Brain Research. Molecular Brain Research·K A Huey, F L Powell

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