Acute idiopathic optic neuritis: not always benign

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Romain DeschampsO Gout

Abstract

Few recent data are available concerning idiopathic optic neuritis (ON). We aimed to describe a large cohort of patients with idiopathic ON. We compared this cohort with patients with ON related to myelin oligodendrocyte glycoprotein (MOG) or ON related to aquaporin-4 (AQP4) antibodies. This was a monocentric retrospective observational study. Inclusion criteria for idiopathic ON were as follows: age ≥ 16 years, follow-up of at least 2 years, negative for antibodies against MOG and AQP4 immunoglobulin G, and no magnetic resonance imaging (MRI) lesions suggestive of demyelination (two brain MRI scans, one at baseline and one during follow-up, and one spinal cord MRI scan). Among 23 patients with idiopathic ON (female, 82.6%; median age, 36 years; median follow-up time, 41.4 months), 56.5% had recurrent ON (median time to a second ON episode, 6 months). The final visual acuity in this group (median, 0; mean, 0.43; range, 0-3) was similar to that in the AQP4 group (n = 18; P-value after Bonferroni correction = 0.936) but worse than that in the MOG group (n = 25; P-value after Bonferroni correction = 0.019). At the last evaluation, visual acuity levels were ≤0.5 and <0.2, respectively, in 36.8% and 21% of the idiopathic ON group, 5...Continue Reading

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Citations

Aug 14, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T Akaishi, I Nakashima
Sep 19, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N ShorR Deschamps
Feb 15, 2019·Current Opinion in Neurology·Alvaro Cobo-CalvoRomain Marignier
Jul 8, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Romain DeschampsOlivier Gout
Nov 19, 2019·Frontiers in Neurology·Laura Navarro CantóBonaventura Casanova Estruch
Apr 25, 2020·Journal of Neuroinflammation·Elisabeth MaillartUNKNOWN OFSEP, SFSEP, and NOMADMUS study groups
Oct 14, 2020·Revue neurologique·N ShorUNKNOWN NOMADMUS study group
Jul 3, 2020·Multiple Sclerosis and Related Disorders·José Miguel AlvesJoana Guimarães
Jul 31, 2021·Journal of Neurology·Laura CacciaguerraMaria A Rocca
Aug 31, 2021·Multiple Sclerosis and Related Disorders·Tetsuya AkaishiIchiro Nakashima

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