Acute in utero exposure to lipopolysaccharide induces inflammation in the pre- and postnatal brain and alters the glial cytoarchitecture in the developing amygdala

Journal of Neuroinflammation
Elaine O'LoughlinKieran W McDermott

Abstract

Maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders such as autism and schizophrenia, as well as seizure development. The amygdala is a brain region involved in the regulation of emotions, and amygdalar maldevelopment due to infection-induced MIA may lead to amygdala-related disorders. MIA priming of glial cells during development has been linked to abnormalities seen in later life; however, little is known about its effects on amygdalar biochemical and cytoarchitecture integrity. Time-mated C57BL6J mice were administered a single intraperitoneal injection of 50 μg/kg lipopolysaccharide (LPS) on embryonic day 12 (E12), and the effects of MIA were examined at prenatal, neonatal, and postnatal developmental stages using immunohistochemistry, real-time quantitative PCR, and stereological quantification of cytoarchitecture changes. Fetal brain expression of pro-inflammatory cytokines (IL-1β, TNFα, and IL-6) was significantly upregulated at 4 h postinjection (E12) and remained elevated until the day of birth (P0). In offspring from LPS-treated dams, amygdalar expression of pro-inflammatory cytokines was also increased on day 7 (P7) and expression was sustained on day 40 (P40). Toll-like receptor (TLR-2...Continue Reading

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Citations

Sep 15, 2019·Journal of Neuroinflammation·Guy C Brown
Dec 19, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jaqueline M WatkinsLinda F Hayward
Nov 23, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Andrea G EdlowStaci Bilbo
Feb 2, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mariko SaitoBhaskar C Das
Apr 26, 2020·Developmental Neurobiology·Jie DongIrina Burd
Aug 28, 2020·Frontiers in Neuroscience·Marissa R KeeverSandra L Rodriguez-Zas
Mar 3, 2020·Frontiers in Pharmacology·Vadim V TarasovGjumrakch Aliev
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Oct 2, 2021·European Archives of Psychiatry and Clinical Neuroscience·Ralf BrischRainer Wolf

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Methods Mentioned

BETA
PCR
flow cytometry

Software Mentioned

GraphPad Prism
ImageJ

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