Acute in vitro and in vivo toxicity of a commercial grade boron nitride nanotube mixture

Nanotoxicology
Vamsi K KodaliAaron D Erdely

Abstract

Boron nitride nanotubes (BNNTs) are an emerging engineered nanomaterial attracting significant attention due to superior electrical, chemical and thermal properties. Currently, the toxicity profile of this material is largely unknown. Commercial grade BNNTs are composed of a mixture (BNNT-M) of ∼50-60% BNNTs, and ∼40-50% impurities of boron and hexagonal boron nitride. We performed acute in vitro and in vivo studies with commercial grade BNNT-M, dispersed by sonication in vehicle, in comparison to the extensively studied multiwalled carbon nanotube-7 (MWCNT-7). THP-1 wild-type and NLRP3-deficient human monocytic cells were exposed to 0-100 µg/ml and C57BL/6 J male mice were treated with 40 µg of BNNT-M for in vitro and in vivo studies, respectively. In vitro, BNNT-M induced a dose-dependent increase in cytotoxicity and oxidative stress. This was confirmed in vivo following acute exposure increase in bronchoalveolar lavage levels of lactate dehydrogenase, pulmonary polymorphonuclear cell influx, loss in mitochondrial membrane potential and augmented levels of 4-hydroxynonenal. Uptake of this material caused lysosomal destabilization, pyroptosis and inflammasome activation, corroborated by an increase in cathepsin B, caspase 1, i...Continue Reading

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Citations

Jun 29, 2018·Nanotoxicology·Eşref Demir, Ricard Marcos
Jan 3, 2020·Environmental Science. Processes & Impacts·Roxana SühringMiriam L Diamond
Jun 10, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Vamsi KodaliAaron Erdely
Jan 13, 2021·Nanomaterials·Tung X Trinh, Jongwoon Kim
Mar 25, 2021·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Hazel LinAlberto Bianco
Nov 10, 2020·Acta Pharmaceutica Sinica. B·Aqu AluXiawei Wei

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