Acute in vivo studies of the Pittsburgh intravenous membrane oxygenator

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
M MachaB G Hattler

Abstract

The efficacy of an innovative intravenous membrane oxygenator (IMO) was tested acutely (6-8 hrs) in seven calves. The IMO prototypes consisted of a central polyurethane balloon within a bundle of hollow fibers with a membrane surface area of 0.14 m2. The IMO devices were inserted through the external jugular vein into the inferior vena cava of anesthetized calves (68.9 +/- 2.3 kg). Rhythmic balloon pulsation (60-120 bpm) was controlled with an intra-aortic balloon pump console. Oxygen sweep gas was delivered through the device at 3.0 L/min. Gas concentrations were monitored continuously by mass spectroscopy. The principal results were as follows: 1) oxygen and carbon dioxide exchange ranged from 125 to 150 ml/min/m2 and 150 to 200 ml/min/m2, respectively; 2) there was at least a 30-50% augmentation of gas exchange with balloon pulsation; 3) maximum exchange occurred with 60-90 bpm balloon pulsations; and 4) hemodynamic parameters remained unchanged. There were no device related complications, and the feasibility of insertion of the device by a cervical cut-down was established. These acute in vivo experiments show that the Pittsburgh IMO device can exchange oxygen and carbon dioxide gases in vivo at levels consistent with this ...Continue Reading

Citations

May 23, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Heide J EashWilliam J Federspiel
Mar 2, 2002·Journal of Biomechanical Engineering·Monica Y GarciaWilliam J Federspiel
Aug 3, 2005·Journal of Biomechanical Engineering·Amador M GuzmánCristina H Amon
May 22, 2007·Journal of Biomechanics·Georg Wolfgang Desch, Hans Werner Weizsäcker
Apr 23, 2014·Artificial Organs·R Garrett JeffriesWilliam J Federspiel
Nov 29, 2002·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Laura W LundWilliam J Federspiel
Aug 24, 1999·Perfusion·B G Hattler, W J Federspiel
Mar 27, 2001·Computer Methods in Biomechanics and Biomedical Engineering·AMADOR M. Guzmán, CRISTINA H. Amon

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