Acute indoramin poisoning: a review of 55 cases reported to the Paris Poison Centre from 1986 t o 2010

Antoine F VillaRobert Garnier


Authors report a retrospective study of all cases of indoramin-only poisoning notified to the Paris poison Centre from 1986 to 2010. Fifty five cases of indoramin self-poisoning were included: 40 adults and 15 children. The mean supposed ingested dose was about 701 mg±464 mg. ECG showed a prolonged QTc interval (equal to or greater than 0.50 s) in 30% of patients. The lowest observed dose for prolonged QTc was 625 mg. This series includes two cases of seizures occurring around two hours after ingestion of 900 and 2 250 mg of indoramin. A review of the literature showed cardiac disorders, with a delayed mechanism of action up until 18 hours after ingestion. Therefore, rapid medical resuscitation and prolonged cardiac monitoring for at least 24 hours after ingestion of 625 mg are recommended.


Sep 1, 1991·British Journal of Clinical Pharmacology·M A James, J V Jones
Jan 1, 1986·Journal of Cardiovascular Pharmacology·G S Butrous, A J Camm
Jan 1, 1986·Journal of Cardiovascular Pharmacology·J L Archibald
Mar 1, 1988·Biopharmaceutics & Drug Disposition·D M PierceR A Franklin
Jan 1, 1988·European Journal of Clinical Pharmacology·D M PierceR A Franklin
Feb 1, 1987·International Journal of Cardiology·M A JamesJ Vann Jones
Feb 1, 1985·British Journal of Clinical Pharmacology·D W HarronR G Shanks
Jan 1, 1984·Clinical and Experimental Pharmacology & Physiology·J L Black, E J Mylecharane
Oct 9, 1982·British Medical Journal·R Hunter
Jan 1, 1982·Current Medical Research and Opinion·G N VolansT Frost
Jan 15, 2008·International Journal of Cardiology·P NisseM Mathieu-Nolf


May 9, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Adam R Bosak, Aaron B Skolnik

Related Concepts

Acute Disease
Antihypertensive Agents
Poison Control Centers
Retrospective Studies
Drug Overdose
Heart Diseases

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.