Acute infections after fracture repair: management with hardware in place

Clinical Orthopaedics and Related Research
Eric RightmireMark Vrahas

Abstract

Managing infections in fractures treated with open reduction and internal fixation is an ongoing dilemma. Little published data exist to support the current practice of treating these infections with retained hardware, irrigation, débridement, and antibiotic suppression. We evaluated the effectiveness of this approach. We identified potential subjects from a central trauma database and selected them based on chart review and specific inclusion and exclusion criteria. We divided the patients into two groups. Patients achieving successful union with original hardware in place were considered as having successful results and patients who required hardware removal before healing were considered to have failed results. Data, including age, gender, tobacco use, diabetic status, site of fracture, Orthopaedic Trauma Association class, open grade, type of fixation, joint involvement, and organism, were gathered and compared between the groups by analysis of variance. Sixty-nine cases were available for analysis. Forty-seven (68%) were successful and 22 (32%) were unsuccessful. Average time to healing was 130 days. Most of the failures occurred within 120 days from the time of injury. Smoking was a major risk factor with a 3.7 times grea...Continue Reading

References

Sep 1, 1992·The Journal of Bone and Joint Surgery. British Volume·C M Court-BrownM M McQueen
Oct 1, 1990·The Journal of Antimicrobial Chemotherapy·P DellamonicaC Argenson
Jan 22, 1970·The New England Journal of Medicine·F A WaldvogelM N Swartz
May 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C M BrandtD R Osmon
Mar 28, 1998·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·G O HofmannV Bühren
Apr 2, 1999·Clinical Orthopaedics and Related Research·J T MaderJ H Calhoun
Sep 7, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P TattevinC Carbon
Nov 24, 2004·Clinical Orthopaedics and Related Research·Steven J VolinKevin L Garvin
Dec 7, 2005·Clinical Orthopaedics and Related Research·Matthew J KraayMichael J Salata
Jan 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C E MarculescuD R Osmon

❮ Previous
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Citations

Nov 29, 2014·TheScientificWorldJournal·Yong-Qing XuXiao-Qing He
Jan 15, 2015·Acta Orthopaedica. Supplementum·Mikko Ovaska
Oct 21, 2015·The Journal of Hand Surgery, European Volume·R Pinder, G Barlow
May 10, 2015·Foot & Ankle Specialist·Matthew R WagonerAndrew J Meyr
Feb 22, 2017·Journal of Orthopaedic Surgery·Christian FangFrankie Leung
Apr 29, 2016·Journal of Orthopaedic Trauma·Ida L GitajnMitchel B Harris
Oct 14, 2014·Archives of Orthopaedic and Trauma Surgery·A J SudaJ Franke
Mar 25, 2017·Orthopaedics & Traumatology, Surgery & Research : OTSR·E MelhemI Ghanem
Jun 27, 2017·Journal of Orthopaedic Trauma·Joshua M LawrenzHeather A Vallier
May 29, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Roli KarguptaShramik Sengupta
Aug 1, 2013·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·D I Vos, M H J Verhofstad
Aug 25, 2015·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·C KleberA Trampuz
Sep 21, 2013·International Orthopaedics·Mohamed Al-MayahiIlker Uçkay
Dec 18, 2013·Archives of Orthopaedic and Trauma Surgery·Sâra AytaçThorsten Guehring
Mar 13, 2014·Journal of Internal Medicine·W Zimmerli
May 24, 2014·Journal of Orthopaedic Trauma·Jesse T TorbertRobert V OʼToole
Apr 3, 2010·The Journal of Bone and Joint Surgery. American Volume·Marschall BerkesUNKNOWN Southeast Fracture Consortium
Mar 31, 2012·Journal of Orthopaedic Trauma·Scott R BassuenerRoy Sanders
Feb 13, 2020·Expert Review of Anti-infective Therapy·Andrew L FosterR Geoff Richards
Feb 19, 2016·The Journal of Trauma and Acute Care Surgery·Cornelius A ThielsBrian D Kim
Aug 24, 2016·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·O Borens, N Helmy
May 19, 2018·Foot & Ankle International·Eric S BaranekJ Turner Vosseller
Aug 20, 2019·EFORT Open Reviews·Sylvain SteinmetzOlivier Borens
Feb 22, 2017·Journal of Orthopaedic Surgery·Christian FangFrankie Leung
May 20, 2015·Clinical Orthopaedics and Related Research·Fuat BilgiliNezahat Gurler
Mar 3, 2020·The Journal of Bone and Joint Surgery. American Volume·William T ObremskeyUNKNOWN ICM Orthopaedic Trauma Work Group*
Feb 2, 2021·The Bone & Joint Journal·Mario MorgensternWillem Jan Metsemakers
Sep 19, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshie AraiSoo-Hong Lee
Apr 18, 2021·Injury·Steven A HortonRobert V O'Toole
Aug 26, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M DepypereW-J Metsemakers

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