Acute inflammatory responses of nanoparticles in an intra-tracheal instillation rat model

PloS One
Andrea L ArmsteadBingyun Li

Abstract

Exposure to hard metal tungsten carbide cobalt (WC-Co) "dusts" in enclosed industrial environments is known to contribute to the development of hard metal lung disease and an increased risk for lung cancer. Currently, the influence of local and systemic inflammation on disease progression following WC-Co exposure remains unclear. To better understand the relationship between WC-Co nanoparticle (NP) exposure and its resultant effects, the acute local pulmonary and systemic inflammatory responses caused by WC-Co NPs were explored using an intra-tracheal instillation (IT) model and compared to those of CeO2 (another occupational hazard) NP exposure. Sprague-Dawley rats were given an IT dose (0-500 μg per rat) of WC-Co or CeO2 NPs. Following 24-hr exposure, broncho-alveolar lavage fluid and whole blood were collected and analyzed. A consistent lack of acute local pulmonary inflammation was observed in terms of the broncho-alveolar lavage fluid parameters examined (i.e. LDH, albumin, and macrophage activation) in animals exposed to WC-Co NP; however, significant acute pulmonary inflammation was observed in the CeO2 NP group. The lack of acute inflammation following WC-Co NP exposure contrasts with earlier in vivo reports regarding W...Continue Reading

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Jan 18, 2018·Current Opinion in Allergy and Clinical Immunology·Anne E Wyman, Stella E Hines
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Methods Mentioned

BETA
lavage
dynamic light scattering
transmission
scanning electron microscopy
enzyme-linked immunosorbent assay
ELISA
Protein Assay
light microscopy

Software Mentioned

GraphPad Prism

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