Acute interstitial pneumonia (Hamman-Rich syndrome) in idiopathic pulmonary fibrosis and bronchoalveolar carcinoma: a case report

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Jiri PlasekArnost Martinek

Abstract

Acute interstitial pneumonia is characterized by rapid progressive dyspnoea degenerating into respiratory failure requiring mechanical ventilation. Acute interstitial pneumonia (AIP) and idiopathic pulmonary fibrosis (IPF) are separate clinic/pathological entities although overlap may be present. It is well-known that patients with IPF have increased risk of lung carcinoma; Adenocarcinoma in connection with IPF is less common. Moreover the subtype of adenocarcinoma, diffuse bronchoalveolar carcinoma has not yet been described. We report the case of 45 yr old former hockey player with increased bilateral reticular shadowing on chest radiograph, dyspnoea, velcro-like crackles, restrictive respiratory disease and mixed high-resolution computed tomography finding. During brief in-patient treatment the patient developed acute respiratory failure accompanied by multiorgan failure and disseminated coagulopathy. Deterioration of the microcirculation was followed by loss of peripheral vascular resistance, which was irreversible even with normalization of the blood gases achieved by extracorporeal membrane oxygenation. At autopsy, bronchoalveolar carcinoma in usual interstitial pneumonia (UIP) combined with areas of alveolar damage with ...Continue Reading

References

Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·M W ZiegenhagenJ Müller-Quernheim
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·R HubbardJ Britton
Aug 25, 2001·The New England Journal of Medicine·T J Gross, G W Hunninghake
Feb 7, 2002·The European Respiratory Journal·E BrambillaY Shimosato
Aug 14, 2002·Mayo Clinic Proceedings·Marie-Christine AubryV Shane Pankratz
Feb 7, 2003·The European Respiratory Journal·A BonaccorsiV Poletti
Jun 17, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dan J RazDavid M Jablons
Nov 6, 2008·BMC Pulmonary Medicine·Jette B KornumHenrik Toft Sørensen
Jun 23, 2009·The American Journal of Pathology·Simona Emilia FlontaAlberto Bardelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

European Journal of Internal Medicine
Manuel Ferreira GomesJosé Braz Nogueira
Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
Justin S SwartzJoseph G Parambil
Respiration; International Review of Thoracic Diseases
Srinivas RajagopalaPritilatha Rout
American Journal of Respiratory and Critical Care Medicine
Chi Ryang ChungYong Chul Lee
© 2022 Meta ULC. All rights reserved