Acute Intoxications Involving Valerylfentanyl Identified at the New York City Office of Chief Medical Examiner.

Journal of Analytical Toxicology
Erin WalshGail Cooper

Abstract

The detection of novel fentanyl analogs in both seized drugs and toxicological specimens has presented a significant challenge to laboratories with respect to identification, sourcing reference drug standards, the time required for method development and ensuring sufficient method sensitivity. The New York City Office of Chief Medical Examiner has included testing for valerylfentanyl as part of a panel of synthetic opioids since May 2017 but did not identify the first valerylfentanyl-positive case until July 2018. Unlike many other illicit fentanyl analogs that were briefly identified before being replaced with a new analog, valerylfentanyl has persisted over time and continues to be identified in New York City acute polydrug intoxications. Since July 2018, a total of 69 cases were identified to be valerylfentanyl positive, but there were no cases where it was the sole intoxicant. Eighty-four percentage of decedents were male, with the majority being Hispanic males (49%) between the ages of 50 and 59 years (39%). The cause of death in all 69 cases involved acute polydrug intoxications, while the manner of death was deemed an accident in 68 cases and undetermined in one case. Concentrations of valerylfentanyl in postmortem blood...Continue Reading

References

Aug 13, 2013·Journal of Analytical Toxicology·UNKNOWN Scientific Working Group for Forensic Toxicology
Jun 8, 2017·Forensic Science International : Synergy·Davide GuerrieriRobert Kronstrand
Jun 8, 2017·Journal of Addiction Medicine·Matthew P PrekupecMichael H Baumann
Dec 1, 2017·Journal of Analytical Toxicology·Alex J KrotulskiBarry K Logan
Oct 30, 2018·Journal of Analytical Toxicology·Joseph H KahlDiane M Boland
Jan 13, 2019·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Michelle L NolanDenise Paone
Jan 18, 2019·MMWR. Morbidity and Mortality Weekly Report·Cody Colon-BerezinDenise Paone
Feb 9, 2019·Neuropharmacology·D Matthew WalentinyPatrick M Beardsley
Mar 25, 2019·Neuropharmacology·Neil B VarshneyaPatrick M Beardsley
Dec 29, 2020·The American Journal of Emergency Medicine·Philip DiSalvoMark K Su

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