Acute intravascular hemolysis secondaryto out-of-group platelet transfusion

Transfusion
L G LarssonD J Ladd

Abstract

Acute intravascular hemolysis is rarely associated with platelet transfusion. Out-of-group single-donor platelets may cause hemolysis if the donor has high-titer ABO hemagglutinins. A 44-year-old woman, blood group A, was recently diagnosed with acute myeloid leukemia and was receiving chemotherapy. After the transfusion of apheresis platelets from a group O donor, back pain, hemoglobinuria, and hemoglobinemia developed, and her Hb dropped by 2.3 g per dL, despite the transfusion of 2 units of RBCs. Investigation revealed acute intravascular hemolysis with a positive DAT due to anti-A(1) on her RBCs. The donor's titer of anti-A(1) was greater than 16,000. Review of published cases raises the possibility that hemolytic reactions to out-of-group platelets may be more frequent since the use of apheresis platelets has increased.

References

Apr 21, 1990·Lancet·V DamjanovicH K van Saene
Apr 21, 1990·Lancet·M F MurphyT A Lister
Jan 1, 1989·Clinical and Laboratory Haematology·M D Reis, Ahmed S Coovadia
Sep 1, 1988·Transfusion·S Murphy
Jul 1, 1966·Transfusion·M Grove-Rasmussen
Mar 1, 1982·Scandinavian Journal of Haematology·B C McLeodT Vaithianathan
Jun 10, 1998·American Journal of Clinical Pathology·G Garratty
Apr 27, 1999·Transfusion Medicine·P MoncharmontE Subtil
Apr 1, 1911·The Journal of Experimental Medicine·R Ottenberg
Mar 1, 1946·American Journal of Clinical Pathology·L H TISDALL, D M GARLAND

Citations

Jul 26, 2003·Transfusion Medicine Reviews·Alan T Tinmouth, John Freedman
Jul 27, 2001·British Journal of Haematology·Anne F Eder, Catherine S Manno
Nov 8, 2002·Transfusion·Susan D RoseffCatherine S Manno
Sep 19, 2002·American Journal of Therapeutics·Heather A Hume, Pierre Limoges
Sep 24, 2008·Blood·Harvey Alter, Harvey Klein
Feb 20, 2009·Anesthesia and Analgesia·Jeanne E Hendrickson, Christopher D Hillyer
Feb 27, 2014·Shock·Geir StrandenesEinar K Kristoffersen
Dec 4, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Alexander B KentonCaraciolo J Fernandes
May 17, 2011·Asian Journal of Transfusion Science·Vishakha V JainS Sambasivaiah
Mar 1, 2012·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Amornrat V RomphrukArunrat Romphruk
Jun 21, 2011·American Journal of Clinical Pathology·Arand PierceEducation Committee of the Academy of Clinical Laboratory Physicians and Scientists
Dec 26, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Cassandra D JosephsonChristopher D Hillyer
May 20, 2015·Internal Medicine·Satoko OkaMasaharu Nohgawa
May 14, 2005·Journal of Clinical Apheresis·Rajendra ChaudharyJai Shanker Shukla
Jul 26, 2003·Transfusion Medicine·M L Barjas-CastroV Castro
May 26, 2004·Transfusion·Jay H Herman, Karen E King
Nov 3, 2005·Journal of Clinical Apheresis·Suneeti SapatnekarRoslyn Yomtovían
Jul 18, 2008·Transfusion·Laura L CoolingRobertson D Davenport
Mar 15, 2012·Transfusion·Magali J FontaineLawrence T Goodnough
May 18, 2012·Transfusion·Suchitra Pandey, Girish N Vyas
Jul 20, 2012·Journal of Clinical Laboratory Analysis·Kamontip KhampanonO Nathalang
Oct 1, 2015·Asian Journal of Transfusion Science·Sheetal MalhotraNeelam Marwaha
Oct 4, 2003·American Journal of Obstetrics and Gynecology·John D Yeast, Frederick Plapp
Nov 5, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·O NathalangY Li
Mar 23, 2017·The Journal of Trauma and Acute Care Surgery·Tamara R BelinAndrew P Cap
Mar 22, 2019·Transfusion·Rachel BeddardLorena Aranda
Jul 11, 2013·Annals of the Royal College of Surgeons of England·S OdakA Clayson
Apr 17, 2004·Journal of Pediatric Hematology/oncology·Anne Angiolillo, N L Luban
May 23, 2013·The Journal of Trauma and Acute Care Surgery·Chelsea R MehrNancy M Dunbar
May 7, 2003·Transfusion Medicine Reviews·Steven KleinmanPierre Robillard
May 10, 2007·Archives of Pathology & Laboratory Medicine·Anne F Eder, Linda A Chambers
Jun 7, 2007·Archives of Pathology & Laboratory Medicine·Mark K FungIra A Shulman

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.