Acute irritation thresholds in subjects with type I--type VI skin

Contact Dermatitis
J P McFaddenD A Basketter

Abstract

It has long been recognized that human skin can be subdivided into simple categories based on their sensitivity to sunlight--from Type I, never tans, always burns, to Type VI, marked constitutive pigmentation. There is also evidence that the more readily sunburnt type of skin is also more susceptible to the effect of irritants. In the present work, the irritancy threshold for sodium lauryl sulfate (SLS) has been assessed using a recently described 4-h acute skin irritation patch test. A total of 110 subjects covering all 6 skin types were examined and their threshold for acute irritancy defined as the lowest concentration of SLS, applied under 4-h occlusion, which would induce a clinically detectable irritant response. The SLS dose response generated using a range of concentrations (0.1%-20%) demonstrated that there was no significant difference between the groups under these test conditions. Even for Type VI skin (n = 25), the dose-response curve fell within the general pattern. These results reinforce the general applicability of predictions of acute irritant potential made in groups of human volunteers.

References

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Jan 1, 1982·Archives of Dermatological Research·P J Frosch, C Wissing
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Jul 17, 1998·Contact Dermatitis·D A BasketterA Lahti

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Citations

Apr 17, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M K RobinsonJ H Fentem
Mar 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J H FentemP A Botham
Sep 11, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J J L JacobsG R Elliott
Aug 12, 1999·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·M K RobinsonD A Basketter
Mar 15, 2000·Journal of Pharmacological and Toxicological Methods·M K RobinsonM A Perkins
Nov 3, 2012·Interdisciplinary Toxicology·David BasketterHelena Kandárová
Jul 17, 1998·Contact Dermatitis·D A BasketterA Lahti
May 22, 2008·International Journal of Cosmetic Science·G Primavera, E Berardesca
Jun 12, 2012·Contact Dermatitis·David A BasketterIan Kimber
Aug 30, 2012·International Journal of Cosmetic Science·E BerardescaH Maibach
Sep 17, 2013·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·E LeeK Shin
Feb 21, 2006·Journal of the American Academy of Dermatology·Susanne AstnerErnesto Gonzalez
Jul 20, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Michael K RobinsonPhillip L Casterton
Aug 22, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J MolinariC Barrichello
Feb 16, 2002·Contact Dermatitis·V FoyD A Basketter
Jun 29, 2005·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
Aug 5, 2004·Contact Dermatitis·David A BasketterMichael K Robinson
Nov 18, 2000·Annals of the New York Academy of Sciences·M K RobinsonM A Perkins

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