PMID: 2485480Jan 1, 1989Paper

Acute ischemic renal failure: review of experimental studies on pathophysiology and potential protective interventions

Renal Failure
M Mohaupt, H J Kramer

Abstract

More than 70% of acute renal failure in man is of circulatory nature and results from hypoxic injury to the kidney. Since intrarenal hemodynamic and metabolic events cannot be accurately assessed in human acute renal failure, various experimental models of renal hypoperfusion or complete interruption of renal blood supply, such as norepinephrine-induced acute renal failure or clamping of the renal artery, have been employed to obtain more direct insight into the pathophysiological events and consequences of hypoxia, although none of these models may truly mimic human acute renal failure. In addition, the severity of experimental acute renal failure, that is, oliguric or nonoliguric acute renal failure resulting from renal hypoperfusion, depends not only on the model employed but also largely on the experimental conditions. In the hemodynamic models a vascular component is incriminated in the initial phase, and persistent tubular tissue dysfunction in the maintenance phase of ischemic acute renal failure. Hypoxic vascular injury will lead to vasoconstriction; a decrease in glomerular filtration pressure, glomerular capillary surface area, and permeability; and thus to a decrease in glomerular filtration rate. In contrast to prev...Continue Reading

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Citations

Sep 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C BlackerR Scholler
May 30, 1996·The New England Journal of Medicine·R ThadhaniJ V Bonventre
Jan 1, 1993·Renal Failure·C M HelouA dos S Rocha
Jul 1, 1994·Clinical and Experimental Hypertension : CHE·F FerranteF Amenta
Mar 1, 1993·Kidney International·N Honda, A Hishida
Jan 10, 2002·Anesthesiology Clinics of North America·W C Wilson, S Aronson
Jan 1, 1994·Renal Failure·G TataranniG Zavagli
Jun 30, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ali Mirza OnderRobert Gustafson
Jan 1, 1994·Renal Failure·I Shilliday, M E Allison
Jul 18, 2001·American Journal of Physiology. Renal Physiology·O EickelbergM Kashgarian

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