Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs

American Journal of Physiology. Heart and Circulatory Physiology
Kathleen C WoulfeBrian L Stauffer

Abstract

Sudden cardiac death from ventricular arrhythmias is more common in adult patients with with heart failure compared with pediatric patients with heart failure. We identified age-specific differences in arrhythmogenesis using a guinea pig model of acute β-adrenergic stimulation. Young and adult guinea pigs were exposed to the β-adrenergic agonist isoproterenol (ISO; 0.7 mg/kg) for 30 min in the absence or presence of flecainide (20 mg/kg), an antiarrhythmic that blocks Na+ and ryanodine channels. Implanted cardiac monitors (Reveal LINQ, Medtronic) were used to monitor heart rhythm. Alterations in phosphorylation and oxidation of ryanodine receptor 2 (RyR2) were measured in left ventricular tissue. There were age-specific differences in arrhythmogenesis and sudden death associated with acute β-adrenergic stimulation in guinea pigs. Young and adult guinea pigs developed arrhythmias in response to ISO; however, adult animals developed significantly more premature ventricular contractions and experienced higher arrhythmia-related mortality than young guinea pigs treated with ISO. Although there were no significant differences in the phosphorylation of left ventricular RyR2 between young and adult guinea pigs, adult guinea pigs expos...Continue Reading

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Citations

Jul 3, 2020·Animal Models and Experimental Medicine·Michael Nguyen-TruongZhijie Wang
Dec 31, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Luther M SwiftNikki Gillum Posnack
Jun 18, 2021·Journal of Molecular and Cellular Cardiology·Kathleen C WoulfeCarmen C Sucharov
Jul 23, 2021·GeroScience·Sabrina ChoiClaudia M Moreno

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Methods Mentioned

BETA
dissection

Software Mentioned

ImageJ
Prism
GraphPad
LINQ

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