Acute ketamine dysregulates task-related gamma-band oscillations in thalamo-cortical circuits in schizophrenia

Brain : a Journal of Neurology
Tineke Grent-'t-JongPeter J Uhlhaas

Abstract

Hypofunction of the N-methyl-d-aspartate receptor (NMDAR) has been implicated as a possible mechanism underlying cognitive deficits and aberrant neuronal dynamics in schizophrenia. To test this hypothesis, we first administered a sub-anaesthetic dose of S-ketamine (0.006 mg/kg/min) or saline in a single-blind crossover design in 14 participants while magnetoencephalographic data were recorded during a visual task. In addition, magnetoencephalographic data were obtained in a sample of unmedicated first-episode psychosis patients (n = 10) and in patients with chronic schizophrenia (n = 16) to allow for comparisons of neuronal dynamics in clinical populations versus NMDAR hypofunctioning. Magnetoencephalographic data were analysed at source-level in the 1-90 Hz frequency range in occipital and thalamic regions of interest. In addition, directed functional connectivity analysis was performed using Granger causality and feedback and feedforward activity was investigated using a directed asymmetry index. Psychopathology was assessed with the Positive and Negative Syndrome Scale. Acute ketamine administration in healthy volunteers led to similar effects on cognition and psychopathology as observed in first-episode and chronic schizoph...Continue Reading

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Citations

May 7, 2020·Reviews in the Neurosciences·Rebecca McMillan, Suresh D Muthukumaraswamy
Aug 18, 2020·Schizophrenia Bulletin Open·Veronica GandaraFiza Singh
Jun 27, 2020·Frontiers in Psychiatry·Sokichi HondaTakuma Mihara
Mar 15, 2019·Proceedings of the National Academy of Sciences of the United States of America·Panos ZanosTodd D Gould
Jun 21, 2021·Neuroscience·Wenlu LiTianzi Jiang
Sep 25, 2021·Psychiatry and Clinical Neurosciences·Yoji Hirano, Peter J Uhlhaas

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