Abstract
Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly being used to treat advanced, refractory chronic heart failure. Herein, we sought to determine the incidence of postoperative acute kidney injury (AKI) in axial-flow (HeartMate II; HM-II) and centrifugal-flow (HVAD) CF-LVAD recipients, as well as the effect of AKI on mortality. The study cohort comprised 520 patients who received a HM-II (n = 398) or HVAD (n = 122) at our center between November 2003 and March 2016. Their records were reviewed to determine the incidence of RIFLE-defined AKI after LVAD implantation. We compared the perioperative characteristics, postoperative complications, and survival rates of the patients with and without AKI and differentiated the outcomes based on device type (HM-II or HVAD). Seventy-five patients (14.4%) developed AKI postoperatively. Patients with AKI after LVAD implantation had significantly reduced survival compared to patients without AKI (p = 0.01). Cox proportional hazards models showed that AKI was a significant independent predictor of mortality (HR = 1.54, p = 0.03). Preoperative mechanical circulatory support and prolonged cardiopulmonary bypass time were independent predictors of AKI. The incidence of AK...Continue Reading
References
Aug 1, 1992·Journal of the American College of Cardiology·D D SchockenE A Ross
Oct 31, 2002·Artificial Organs·Hiroyuki OhnishiYoshiyuki Taenaka
Jan 13, 2004·Journal of the American College of Cardiology·Daniel E FormanHarlan M Krumholz
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rinaldo BellomoUNKNOWN Acute Dialysis Quality Initiative workgroup
Sep 15, 2005·Circulation·Sharon Ann HuntUNKNOWN Heart Rhythm Society
Apr 25, 2006·The Annals of Thoracic Surgery·Javed ButlerRichard N Pierson
Mar 14, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M S MulliganS Murray
Nov 15, 2008·Journal of the American College of Cardiology·Claudio RoncoRinaldo Bellomo
Apr 1, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Forum KamdarRanjit John
Nov 19, 2009·The New England Journal of Medicine·Mark S SlaughterUNKNOWN HeartMate II Investigators
Mar 12, 2011·Anesthesiology·Avinash B Kumar, Manish Suneja
Oct 30, 2012·The Annals of Thoracic Surgery·Jamil BorgiJeffrey A Morgan
Dec 25, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nader MoazamiRandall C Starling
Apr 2, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kevin G SoucyMark S Slaughter
Dec 11, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Tal HasinSoon J Park
Jan 15, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jennifer A CowgerFrancis D Pagani
Jan 15, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ashwin K RavichandranScott Silvestry
Mar 1, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Guruprasad A GiridharanMark S Slaughter
Mar 23, 2015·Heart Failure Reviews·T R TrompJ A Joles
Jan 27, 2018·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Nastasya VolkovicherJeffrey A Morgan
Citations
Feb 24, 2019·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Y SawaT Yamaoka
Aug 23, 2019·Interactive Cardiovascular and Thoracic Surgery·Daniel S FlorissonAndrew E Newcomb
Jan 7, 2020·Artificial Organs·Wataru HijikataOsamu Maruyama
May 22, 2020·Renal Failure·Charat ThongprayoonKianoush Kashani
Apr 13, 2020·Artificial Organs·Benjamin MantellSabrina Law
Feb 19, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Umang ParikhSubhasis Chatterjee
Jul 13, 2021·Interactive Cardiovascular and Thoracic Surgery·Hongtao TieSabrina Martens
Aug 5, 2021·European Journal of Clinical Investigation·Alessia GambaroFlavio Luciano Ribichini