Acute Kidney Injury Can Predict In-Hospital Mortality in Elderly Patients with COVID-19 in the ICU: A Single-Center Study

Clinical Interventions in Aging
Qinglin LiYue Cai

Abstract

Severe or critical patients with coronavirus disease 2019 (COVID-19) are at increased risk for developing acute kidney injury (AKI). However, the rate of AKI in patients of different severities and independent predictive factors associated with AKI are not well understood. We enrolled 107 severely or critically ill elderly patients with COVID-19 who were admitted to the intensive care unit (ICU) in Wuhan, China. AKI was defined according to the 2012 KDIGO criteria. We explored the association between AKI and in-hospital mortality using logistic regression. A predictive nomogram was formulated to predict the AKI development of patients with COVID-19 based on multivariate logistic regression. A total of 107 elderly patients were enrolled during the study period. The mean age was 70 (64-78) years, and 69 (64.5%) were men. For the 107 patients, the degree of severity of COVID-19 was categorized as 37 patients with the severe type (34.6%) and 70 patients with the critical type (65.4%). Overall, 48 of the 107 patients (44.9%) developed AKI during their hospitalization, while AKI occurred in 7 (18.9%) out of the 37 severe patients and 41 (44.9%) out of the 70 critical patients. Of the AKI patients, 35.4% (17/48) required continuous re...Continue Reading

References

Jan 28, 2005·Kidney International·Kwok Hong ChuKar Neng Lai
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Jan 25, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yafang WangUNKNOWN ISN AKF 0by25 China Consortium
Oct 21, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yudong Yin, Richard G Wunderink
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 20, 2020·JAMA : the Journal of the American Medical Association·Matt ArentzMelissa Lee
Apr 1, 2020·The New England Journal of Medicine·Pavan K BhatrajuCarmen Mikacenic
Apr 4, 2020·American Journal of Respiratory and Critical Care Medicine·Yingzhen DuGuogang Xu
Apr 6, 2020·Kidney International·Yichun ChengGang Xu
Apr 7, 2020·JAMA : the Journal of the American Medical Association·Giacomo GrasselliUNKNOWN COVID-19 Lombardy ICU Network
Apr 11, 2020·American Journal of Respiratory and Critical Care Medicine·Yun FengJieming Qu
Apr 19, 2020·Chest·Ruchong ChenUNKNOWN Medical Treatment Expert Group for COVID-19
Apr 30, 2020·Journal of the American Society of Nephrology : JASN·Guangchang PeiGang Xu
May 16, 2020·Critical Care : the Official Journal of the Critical Care Forum·Yuan YuYou Shang
May 18, 2020·Kidney International·Jamie S HirschUNKNOWN Northwell Nephrology COVID-19 Research Consortium
May 18, 2020·The Lancet. Respiratory Medicine·Claudio RoncoFaeq Husain-Syed
Jun 14, 2020·Intensive Care Medicine·Paul GabarreLara Zafrani

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Citations

Jun 22, 2021·Journal of Intensive Care Medicine·Victor P GazivodaOry Wiesel
Jul 3, 2021·International Journal of Molecular Sciences·Iwona Smarz-WidelskaWojciech Załuska
Aug 8, 2021·Critical Care : the Official Journal of the Critical Care Forum·Michiel T U SchuijtUNKNOWN PRoVENT–COVID Collaborative Group

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