Acute kidney injury due to COVID-19 and the circadian rhythm.

Medical Hypotheses
Merve MercanNurettin Abacıoğlu


The COVID-19 pandemic caused by the novel coronavirus (SARS-CoV-2) affects several organs including the kidneys. When examining patients with acute kidney injury (AKI) due to COVID-19, it is important to consider the circadian rhythm because in addition to its biological clock function, disruption of the circadian rhythm has been reported to be associated with the pathogenesis of several disorders, including AKI. Angiotensin-converting enzyme 2 (ACE2), an important component of the renin-angiotensin-aldosterone system (RAAS), displays circadian rhythmicity. Studies have shown that over-expression of human ACE2 increases the replication of SARS-CoV-2, which may lead to disruptions and tissue damage due to the suppression of the brain and muscle ARNT-like protein-1(Bmal1) gene and high pro-inflammatory cytokines expressions in the tissues. Therefore, understanding and regulating the circadian rhythm and expression pattern of the key components of RAAS can prevent or reduce the severity of acute kidney injury that may occur with COVID-19 infection.


Dec 17, 1976·Archives of Toxicology·M Hilfenhaus
Jun 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·R KalaA Eisalo
May 12, 2000·Science·L P ShearmanS M Reppert
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rinaldo BellomoUNKNOWN Acute Dialysis Quality Initiative workgroup
Aug 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shigeki ShimbaMasakatsu Tezuka
Oct 14, 2005·Kidney International·Carlos M FerrarioMark C Chappell
Mar 12, 2008·Hypertension·Thomas M Coffman, Steven D Crowley
Feb 23, 2011·Current Opinion in Pharmacology·L Gabriel NavarHiroyuki Kobori
Nov 17, 2015·Sleep Medicine Clinics·Tomas S AndreaniRavi Allada
Jun 24, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ritsuko MatsumuraMakoto Akashi
Aug 17, 2016·Proceedings of the National Academy of Sciences of the United States of America·Rachel S EdgarAkhilesh B Reddy
Oct 1, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xiaodong ZhuangJane A McKeating
Feb 23, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhenguang ZhangAndrew S I Loudon
Sep 13, 2019·Nature Communications·Shaon SenguptaGarret A FitzGerald
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Apr 6, 2020·Kidney International·Yichun ChengGang Xu
Apr 11, 2020·Nature Reviews. Nephrology·Claudio Ronco, Thiago Reis
Apr 21, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Guqin ZhangHuaqin Pan
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Safiya RichardsonTheodoros P Zanos
Apr 24, 2020·Lancet·Zsuzsanna VargaHolger Moch
Apr 29, 2020·Emerging Microbes & Infections·Jing SunYi-Min Li
Apr 30, 2020·Journal of the American Society of Nephrology : JASN·Guangchang PeiGang Xu
May 18, 2020·Kidney International·Jamie S HirschUNKNOWN Northwell Nephrology COVID-19 Research Consortium
Jul 3, 2020·Frontiers in Immunology·Dina RagabRamy Salem
Sep 24, 2020·Revista da Associação Médica Brasileira·Samuel Átila Rodrigues NogueiraMaria Elizabeth Pereira Nobre

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

Zeitschrift Für Klinische Chemie Und Klinische Biochemie
H KaulhausenH Vetter
BioRxiv : the Preprint Server for Biology
X. ZhuangJane A McKeating
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Stephany BeyerstedtÉrika Bevilaqua Rangel
© 2021 Meta ULC. All rights reserved