Acute Kidney Injury Following Cardiopulmonary Bypass in Children - Risk Factors and Outcomes

Circulation Journal : Official Journal of the Japanese Circulation Society
Seon Hwa LeeTae Gyoon Yoon

Abstract

Acute kidney injury (AKI) is the most common and most serious complication following heart surgery. We aimed to determine the prevalence of, and risk factors for, AKI following pediatric cardiac surgery.Methods and Results:We retrospectively analyzed 135 patients aged ≤18 years who underwent cardiac surgery for congenital heart defects; by RACHS-1 category, 58 patients (43%) had an operative risk score ≥3. AKI was defined and classified using the pediatric pRIFLE criteria (Pediatric Risk, Injury, Failure, Loss, and End-stage Kidney Disease); 19 patients (14.1%) developed AKI: 17 had AKI with a severity classified as risk (R) and 2 had AKI classified as injury (I). Body weight, height, body surface area, and preoperative mechanical ventilation were all independently associated with AKI development (P=0.038, 0.040, 0.033 and 0.008, respectively). Preoperative ventilation strongly correlated with AKI severity. Higher pRIFLE classification positively correlated with increased incidence of peritoneal dialysis, increased postoperative mechanical ventilation duration, and longer hospital stay (P=0.009, 0.039 and 0.042, respectively). In this study, we found a low prevalence of postoperative AKI in pediatric patients undergoing severe ...Continue Reading

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Citations

Dec 7, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Fu-Shan XueGui-Zhen Yang
Dec 7, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Seon Hwa Lee, Soo-Jin Kim
Sep 5, 2017·Nature Reviews. Nephrology·Ying Wang, Rinaldo Bellomo
Mar 30, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Denise C HassonKatja M Gist
May 20, 2020·Cardiology in the Young·Sara Rodriguez-LopezCatherine Morgan
Jul 29, 2020·Asian Cardiovascular & Thoracic Annals·Michael CaesarioBudi Rahmat
Aug 11, 2020·Kidney Research and Clinical Practice·Aditya SharmaRupesh Raina
Oct 9, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Jef Van den EyndeDjalila Mekahli
Nov 5, 2021·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Ying Kiat TanTheo Kofidis

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