Abstract
Coronavirus disease 2019 (COVID-19) is associated with higher risk of AKI. We aimed to describe rates and characterize predictors and health outcomes associated with AKI in a national cohort of US veterans hospitalized with COVID-19. In a cohort of 5216 US veterans hospitalized with COVID-19 identified through July 23, 2020, we described changes in serum creatinine and examined predictors of AKI and the associations between AKI, health resource utilization, and death, utilizing logistic regressions. We characterized geographic and temporal variations in AKI rates and estimated variance explained by key variables utilizing Poisson regressions. In total, 1655 (32%) participants had AKI; 961 (58%), 223 (13%), and 270 (16%) met Kidney Disease Improving Global Outcomes definitions of stage 1, 2, and 3 AKI, respectively, and 201 (12%) received KRT. Eight percent of participants had AKI within 1 day of hospitalization, and 47% did not recover to baseline serum creatinine by discharge. Older age, Black race, male gender, obesity, diabetes, hypertension, and lower eGFR were significant predictors of AKI during hospitalization with COVID-19. AKI was associated with higher mechanical ventilation use (odds ratio, 6.46; 95% confidence inter...Continue Reading
References
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
Feb 18, 1997·Circulation·G M ChertowJ Daley
Jan 31, 2002·Nephron·Mark D Okusa
Dec 22, 2004·Annals of Internal Medicine·Steven M AschEve A Kerr
Oct 15, 2005·Medical Care·Hude QuanWilliam A Ghali
Apr 4, 2008·Kidney International·C Y HsuA S Go
Mar 27, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew S Levey, Lesley A Stevens
Jan 25, 2012·The Annals of Thoracic Surgery·Alessandro ParolariUNKNOWN Monzino Research Group on Cardiac Surgery Outcomes
Aug 3, 2012·Kidney International·Ziyad Al-AlyAnn M O'Hare
Aug 14, 2012·Pharmacoepidemiology and Drug Safety·Charles E LeonardBrian L Strom
Aug 15, 2012·Nephron. Clinical Practice·Arif Khwaja
Jul 20, 2013·BMC Nephrology·Donald G KlepserGary L Cochran
Sep 10, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Yan XieZiyad Al-Aly
Mar 30, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Benjamin BoweZiyad Al-Aly
Aug 30, 2016·KI Reports·Benjamin BoweZiyad Al-Aly
Dec 16, 2017·Kidney International·Yan XieZiyad Al-Aly
Jun 28, 2018·The New England Journal of Medicine·Amy J H Kind, William R Buckingham
Aug 7, 2018·Kidney International·Yan XieZiyad Al-Aly
Jan 16, 2019·JAMA Network Open·Benjamin BoweZiyad Al-Aly
May 31, 2019·BMJ : British Medical Journal·Yan XieZiyad Al-Aly
Oct 14, 2019·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ziyad Al-AlyYan Xie
Nov 21, 2019·JAMA Network Open·Benjamin BoweZiyad Al-Aly
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Mar 14, 2020·Scientific Reports·Benjamin BoweZiyad Al-Aly
Mar 17, 2020·The Lancet Infectious Diseases·David BaudGuillaume Favre
Apr 3, 2020·Intensive Care Medicine·Xiu-Wu PanXin-Gang Cui
Apr 6, 2020·Kidney International·Yichun ChengGang Xu
Apr 25, 2020·Kidney International·Hua SuChun Zhang
May 6, 2020·Journal of the American Society of Nephrology : JASN·Daniel BatlleUNKNOWN COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group
May 12, 2020·The Journal of Infection·Jun Jie NgAndrew M T L Choong
May 18, 2020·Kidney International·Jamie S HirschUNKNOWN Northwell Nephrology COVID-19 Research Consortium
May 18, 2020·The Lancet. Respiratory Medicine·Claudio RoncoFaeq Husain-Syed
May 23, 2020·Lancet·Matthew J CummingsMax R O'Donnell
May 28, 2020·The New England Journal of Medicine·Eboni G Price-HaywoodLeonardo Seoane
May 31, 2020·BMJ : British Medical Journal·Michael G ArgenzianoRuijun Chen
Aug 19, 2020·JAMA Network Open·Baligh R YehiaJoseph Cacchione
Sep 12, 2020·Diabetes Care·Yan XieZiyad Al-Aly
Citations
Dec 17, 2020·BMJ : British Medical Journal·Yan XieZiyad Al-Aly
Jan 11, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dennis G MoledinaF Perry Wilson
Feb 28, 2021·Journal of the American Society of Nephrology : JASN·Paul M Palevsky
Mar 7, 2021·Kidney International·Abby BasalelyChristine B Sethna
Mar 10, 2021·KI Reports·Faeq Husain-SyedClaudio Ronco
Mar 11, 2021·JAMA Network Open·James NugentF Perry Wilson
Apr 2, 2021·Environmental Health Perspectives·Benjamin BoweZiyad Al-Aly
Mar 30, 2021·Frontiers in Physiology·Marie-Bénédicte Le StangNahid Tabibzadeh
Feb 26, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dion GroothofStephan J L Bakker
May 14, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ryan MurrayHolly Kramer
Apr 23, 2021·Nature·Ziyad Al-AlyBenjamin Bowe
May 21, 2021·Journal of the American Heart Association·Yan XieZiyad Al-Aly
May 25, 2021·Current Opinion in Nephrology and Hypertension·Shweta PunjAneesha A Shetty
Jun 9, 2021·Journal of General Internal Medicine·Nipith CharoenngamCaroline M Apovian
Jun 29, 2021·JAMA Internal Medicine·Yan XieZiyad Al-Aly
Apr 23, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Divya BajpaiTukaram E Jamale
Jun 22, 2021·Frontiers in Medicine·Precil Diego Miranda de Menezes NevesAmérico Lourenço Cuvello-Neto
Jun 11, 2021·Kidney International·Bethany C BirkeloEdward D Siew
Jul 9, 2021·Renal Failure·Zhengying FangJingyuan Xie
Aug 13, 2021·BMC Public Health·Jie XuHaiyan Yang
Aug 13, 2021·International Urology and Nephrology·Vassilios LiakopoulosNikolaos Papanas
Aug 18, 2021·BMJ Open·Miao CaiZiyad Al-Aly
Aug 20, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Suzanne M BoyleCrystal A Gadegbeku
Aug 17, 2021·Der Nephrologe·Jan BöckhausOliver Gross
Aug 22, 2021·Chest·Christopher S KingSteven D Nathan
Sep 10, 2021·Reviews in Medical Virology·Mohammad ZareiMehdi Ghasemi
Sep 10, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Susan E Quaggin, Benjamin D Humphreys
Aug 28, 2021·American Journal of Physiology. Renal Physiology·Steven Menez, Chirag R Parikh
Jul 2, 2021·Clinical and Experimental Nephrology·Gaetano AlfanoUNKNOWN Modena Covid-19 Working Group (MoCo19)
Sep 18, 2021·Current Opinion in Nephrology and Hypertension·Daniel CottamLui G Forni
Jul 7, 2021·Nature Reviews. Nephrology·Matthieu LegrandVincenzo Cantaluppi
May 7, 2021·Arthritis & Rheumatology·Bryant R EnglandTed R Mikuls
Sep 3, 2021·Journal of the American Society of Nephrology : JASN·Benjamin BoweZiyad Al-Aly
Nov 14, 2021·Nature Communications·Yan XieZiyad Al-Aly
Jun 22, 2021·CJC Open·Rhian M TouyzColin Berry