Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Megan J KirkleyNeonatal Kidney Collaborative (NKC)

Abstract

Acute kidney injury (AKI) is common in neonatal encephalopathy (NE) and is associated with worse outcomes. Our objectives were to determine the incidence, risk factors, and outcomes of AKI in infants with NE. We performed a retrospective analysis of infants ≥ 34 weeks' gestational age with a diagnosis of NE from the Analysis of Worldwide Acute Kidney injury Epidemiology in Neonates (AWAKEN) database. AKI was defined using the modified Kidney Disease Improving Global Outcomes criteria. Perinatal and postnatal factors were evaluated. Multivariate logistic and linear regressions were performed. One hundred and thirteen patients with NE were included. 41.6% (47) developed AKI. Being born outside the admitting institution (OR 4.3; 95% CI 1.2-14.8; p = 0.02), intrauterine growth restriction (OR 10.3, 95% CI 1.1-100.5; p = 0.04), and meconium at delivery (OR 2.8, 95% CI 1.04-7.7; p = 0.04) conferred increased odds of AKI. After controlling for confounders, infants with AKI stayed in the hospital an average of 8.5 days longer than infants without AKI (95% CI 0.79-16.2 days; p = 0.03). In this multi-national analysis, several important perinatal factors were associated with AKI and infants with both NE and AKI had longer length of stay ...Continue Reading

References

Dec 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M G Karlowicz, R D Adelman
Oct 12, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·R H Pfister, R F Soll
Nov 15, 2012·The Journal of Pediatrics·David T SelewskiSubrata Sarkar
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Susan E JacobsPeter G Davis
May 15, 2013·Pediatrics·J Bryan Carmody, Jennifer R Charlton
Jun 16, 2014·The Journal of Pediatrics·Bernardo KracerHenry C Lee
Oct 30, 2014·African Health Sciences·Dan AlaroLucy Wanaiana
Jul 15, 2015·Pediatrics·David T SelewskiAlison L Kent
Aug 4, 2016·Frontiers in Pediatrics·Jennifer G JettonUNKNOWN Neonatal Kidney Collaborative
Dec 14, 2016·The New England Journal of Medicine·Ahmad KaddourahUNKNOWN AWARE Investigators
Jun 16, 2017·Clinical and Experimental Nephrology·Vikas ChowdharyMaroun J Mhanna
Aug 23, 2017·Pediatrics·Joseph T FlynnUNKNOWN SUBCOMMITTEE ON SCREENING AND MANAGEMENT OF HIGH BLOOD PRESSURE IN CHILDREN
May 8, 2018·The Lancet Child & Adolescent Health·Jennifer G JettonUNKNOWN Neonatal Kidney Collaborative (NKC)
May 8, 2018·Pediatric Quality & Safety·Stephanie L BourqueCassidy A Delaney

❮ Previous
Next ❯

Citations

Aug 23, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Peter N Johnson, Jamie L Miller
Sep 20, 2019·Pediatric Research·David T SelewskiUNKNOWN Neonatal Kidney Collaborative
Oct 13, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Heidi J MurphyJennifer G Jetton
Sep 7, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Matthew W HarerDavid J Askenazi
Mar 3, 2020·Frontiers in Pediatrics·David Joseph Askenazi
Jul 19, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Michelle C StarrSangeeta Hingorani
Nov 6, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Amanda M Uber, Scott M Sutherland
Apr 2, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yang WuXiaoping Jiang
Dec 30, 2020·The Journal of International Medical Research·Ebru Turkoglu UnalSumer Sutcuoglu
Jan 16, 2021·Pediatric Research·Parvesh Mohan GargKeia R Sanderson
Feb 18, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michelle C Starr, Shina Menon
Mar 24, 2021·Critical Care Clinics·Keegan J KavanaughAlison L Kent
Mar 6, 2021·Kidney Research and Clinical Practice·Sidharth K SethiRupesh Raina
May 15, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Tara L DuPontRobin K Ohls
May 21, 2021·Pediatric Research·Sanjay WazirRupesh Raina
Sep 5, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Michelle C StarrTahagod H Mohamed
Oct 3, 2021·Pediatrics·Michelle C StarrUNKNOWN Neonatal Kidney Collaborative Board
Jan 13, 2022·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sidharth Kumar SethiSanjay Wazir

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Mohamed A ShalabyJameela A Kari
Pediatric Research
Jennifer R CharltonNeonatal Kidney Collaborative (NKC)
Critical Care : the Official Journal of the Critical Care Forum
Sean M BagshawANZICS Database Management Committee
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Megan McFerson SooHooKatja M Gist
© 2022 Meta ULC. All rights reserved