Acute kidney injury in patients with nephrotic syndrome undergoing contrast-enhanced CT for suspected venous thromboembolism: a propensity score-matched retrospective cohort study

European Radiology
Shu Min TaoLong Jiang Zhang

Abstract

To determine whether intravenous iodinated contrast material administration increases the risk of acute kidney injury (AKI) in patients with nephrotic syndrome undergoing contrast-enhanced CT. Patients with nephrotic syndrome undergoing contrast-enhanced CT were retrospectively identified (n = 701). Control group consisted of patients with nephrotic syndrome receiving non-contrast CT (n = 1053). Two different 1:1 propensity score matching models using three or 10 variables were developed for each estimated glomerular filtration (eGFR) subgroup. Incidence of post-CT AKI for the two groups was assessed and compared by standard AKI criteria and Acute Kidney Injury Network (AKIN) criteria. After matching with three variables, the AKI incidence in the contrast-enhanced CT and non-contrast CT groups was 2.7% vs 2.5% (standard AKI criteria) and 4.2% vs. 6.7% (AKIN criteria) (p = 1.00 and 0.05), respectively. After matching with 10 variables, AKI incidences were 3.1% vs. 2.6% (standard AKI criteria) and 4.1% vs. 7.4% (AKIN criteria) (p = 0.72 and 0.03), respectively. AKI incidences of each eGFR subgroup in the contrast-enhanced CT group were not higher than in the non-contrast CT group (lowest p = 0.46). Intravenous contrast material a...Continue Reading

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Citations

Nov 12, 2019·Japanese Journal of Radiology·Yoshitaka IsakaUNKNOWN Japanese Society of Nephrology, Japan Radiological Society, and Japanese Circulation Society Joint Working Group
Nov 12, 2019·Clinical and Experimental Nephrology·Yoshitaka IsakaUNKNOWN Japanese Society of Nephrology, Japan Radiological Society, and Japanese Circulation Society Joint Working Group
Nov 12, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshitaka IsakaUNKNOWN Japanese Circulation Society Joint Working Group

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