Acute kidney injury: preclinical innovations, challenges, and opportunities for translation

Canadian Journal of Kidney Health and Disease
Samuel A SilverJeffrey G Dickhout

Abstract

Acute kidney injury (AKI) is a clinically important condition that has attracted a great deal of interest from the biomedical research community. However, acute kidney injury AKI research findings have yet to be translated into significant changes in clinical practice. This article reviews many of the preclinical innovations in acute kidney injury AKI treatment, and explores challenges and opportunities to translate these finding into clinical practice. MEDLINE, ISI Web of Science. This paper details areas in biomedical research where translation of pre-clinical findings into clinical trials is ongoing, or nearing a point where trial design is warranted. Further, the paper examines ways that best practice in the management of AKI can reach a broader proportion of the patient population experiencing this condition. This review highlights pertinent literature from the perspective of the research interests of the authors for new translational work in AKI. As such, it does not represent a systematic review of all of the AKI literature. Translation of findings from biomedical research into AKI therapy presents several challenges. These may be partly overcome by targeting populations for interventional trials where the likelihood of ...Continue Reading

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Citations

May 7, 2016·International Journal of Molecular Sciences·Pu DuannPei-Hui Lin
Jun 18, 2016·Oxidative Medicine and Cellular Longevity·Aleksandra KezicMilica Bajcetic
May 18, 2020·International Journal of Molecular Sciences·Jihye KwakHyun-Jung Kim
Oct 23, 2019·Canadian Journal of Kidney Health and Disease·Paraish S MisraDavid Collister
Oct 16, 2020·Nephrology·Ixchel Lima-Posada, Norma A Bobadilla

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Methods Mentioned

BETA
protein folding

Clinical Trials Mentioned

NCT01602328
NCT01275612
NCT01429038
NCT00752479
NCT00658073
NCT00734396

Software Mentioned

NephroCheck®

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