Acute Kidney Injury: Tubular Markers and Risk for Chronic Kidney Disease and End-Stage Kidney Failure

Blood Purification
Hon Liang TanQi Qian

Abstract

Acute kidney injury (AKI) is a common clinical syndrome directly related to patient short-term and long-term morbidity and mortality. Over the last decade, the occurrence rate of AKI has been increasing, and there has also been a growing epidemic of chronic kidney diseases (CKD) and end-stage kidney disease (ESRD) linked to severe and repeated episodes of AKIs. The detection and management of AKI are currently far from satisfactory. A large proportion of AKI patients, especially those with preexisting CKD, are at an increased risk of non-resolving AKI and progressing to CKD and ESRD. Proposed pathological processes that contribute to the transition of AKI to CKD and ESRD include severity and frequency of kidney injury, alterations of tubular cell phenotype with cells predominantly in the G2/M phase, interstitial fibrosis and microvascular rarification related to loss of endothelial-pericyte interactions and pericyte dedifferentiation. Innate immune responses, especially dendritic cell responses related to inadequate adenosine receptor (2a)-mediated signals, autophagic insufficiency and renin-angiotensin system activation have also been implicated in the progression of AKI and transitions from AKI to CKD and ESRD. Although promi...Continue Reading

Citations

Sep 25, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Rakhi MaiwallShiv K Sarin
Nov 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Weiwei KongHua Zhou
Feb 1, 2018·American Journal of Physiology. Renal Physiology·Cierra N SharpLeah J Siskind
Feb 13, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Elliyeh GhadrdanZahra Jahangard-Rafsanjani
Sep 3, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Dong-Hyuk LeeSeong-Uk Park
Aug 9, 2020·Frontiers in Physiology·Talita Guerreiro Rodrigues HúngaroRonaldo Carvalho Araújo
Nov 23, 2021·Physiological Reports·Gaurav BaranwalJoseph M Rutkowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.