PMID: 9176576Mar 1, 1997Paper

Acute lead encephalopathy in early infancy--clinical presentation and outcome

Annals of Tropical Paediatrics
A al KhayatM R Alidina

Abstract

We studied 19 infants with a mean age of 3.8 months who presented with features consistent with acute lead encephalopathy following the use of traditional medicines. All presented with convulsions; CT scans of the brain on admission showed brain oedema in four, atrophy in four and normal findings in 11. Cerebrospinal fluid analysis in nine patients showed pleocytosis in six and a high protein content in eight. The median lead level in these 19 infants which encephalopathy was 3.6 mumol/l (74.5 micrograms/dl). Seven had a mean lead level of only 2.7 mumol/l (56.9 micrograms/dl) which is much below 70 micrograms/dl, the level usually proposed as the threshold for encephalopathy. Thirteen infants developed brain damage during follow-up; statistical analysis correlated the lead level at 2 months post chelation with an abnormal neurological outcome. Our findings indicate that in very young infants acute lead encephalopathy may occur at lead level lower than previously reported.

References

Sep 30, 1978·British Medical Journal·A R AliM Aslam
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Sep 1, 1986·Annals of Tropical Paediatrics·H RahmanN Menon
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Citations

May 23, 2002·Journal of Computer Assisted Tomography·Meriç TüzünBaki Hekimoğlu
Dec 9, 2003·International Journal of Environmental Health Research·Andrew HardyRagini Vaishnav
Jul 15, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Viroj Wiwanitkit, Jamsai Suwansaksri
Oct 16, 2010·Environmental Health Perspectives·Kim M CecilBruce P Lanphear
May 13, 2003·Clinical Pediatrics·E Ernst
Jun 1, 2000·Indian Journal of Pediatrics·V KalraC S Sharma
Sep 17, 2004·International Journal of Environmental Health Research·H H AngM Kiyoshi

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