PMID: 1211109Dec 19, 1975Paper

Acute lead encephalopathy in the guinea pig

Acta Neuropathologica
T W Bouldin, M R Krigman

Abstract

Acute lead encephalopathy was induced in adult guinea pigs with daily oral doses of lead carbonate. Cerebral capillaries were examined by electron microscopy, and the blood-brain barrier (B-BB) evaluated with Evans blue and horseradish peroxidase. Brain lead levels were also determined during the developing encephalopathy. There was no cerebral capillary alteration or demonstrable B-BB dysfunction. Brain lead concentrations increased over the 5-day period. The encephalopathy in the absence of any vascular alteration suggests that lead can produce a primary toxic effect at the neuronal level.

References

Dec 1, 1974·Archives of Neurology·G W GoldsteinI Diamond
Jan 1, 1974·Acta Neuropathologica·S RoyH M Zimmerman
Jan 1, 1971·Virchows Archiv. A: Pathology. Pathologische Anatomie·J A ThomasM Thomas
Jan 1, 1970·The Journal of Comparative Neurology·D W Caley, D S Maxwell
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky
Jul 1, 1967·The Journal of Cell Biology·T S Reese, M J Karnovsky

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Citations

Jan 1, 1979·Folia Psychiatrica Et Neurologica Japonica·K Nagatoshi
Nov 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·J N Wu, E Tiffany-Castiglioni
Jan 1, 1983·Acta Neuropathologica·R SundströmP Sourander
Nov 1, 1977·Toxicology and Applied Pharmacology·G T BarthalmusM R Krigman

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