Acute leukemias in children with Down syndrome

Hematology/oncology Clinics of North America
C Michel ZwaanParesh Vyas

Abstract

Children with Down syndrome have an increased risk for developing both acute myeloid as well as lymphoblastic leukemia. These leukemias differ in presenting characteristics and underlying biology when compared with leukemias occurring in non-Down syndrome children. Myeloid leukemia in children with Down syndrome is preceded by a preleukemic clone (transient leukemia or transient myeloproliferative disorder), which may disappear spontaneously, but may also need treatment in case of severe symptoms. Twenty percent of children with transient leukemia subsequently develop myeloid leukemia. This transition offers a unique model to study the stepwise development of leukemia and of gene dosage effects mediated by aneuploidy.

References

Mar 21, 2002·Journal of Pediatric Hematology/oncology·Fawaz Al-KasimUNKNOWN Pediatric Oncology Group
Aug 13, 2002·Nature Genetics·Joshua WechslerJohn D Crispino
Sep 20, 2002·Blood·James W VardimanRichard D Brunning
Apr 18, 2003·Lancet·Nancy J Roizen, David Patterson
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yaddanapudi Ravindranath
Dec 6, 2003·Blood·Momin AhmedParesh Vyas
Sep 16, 2004·Pediatric Blood & Cancer·Mylène BassalLinda C Stork
Sep 25, 2004·Pediatric Blood & Cancer·Jeffrey W Taub, Yubin Ge
Jan 5, 2005·Nature Reviews. Cancer·Johann K Hitzler, Alvin Zipursky
Feb 15, 2005·Early Human Development·Mel Greaves
Mar 10, 2005·British Journal of Haematology·Bernward ZellerUNKNOWN Nordic Society of Paediatric Haematology and Oncology (NOPHO)
Jul 16, 2005·Pediatric Hematology and Oncology·Manuel SteinerUNKNOWN Austrian Berlin-Frankfurt-Münster Group
Sep 15, 2005·International Journal of Hematology·Alan B Cantor
Oct 26, 2005·Leukemia Research·Henrik HasleMette Østergaard
Nov 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guido MarcucciClara D Bloomfield
Dec 17, 2005·The Journal of Pediatrics·Yvette C M de HinghEsther de Vries
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jean-Pierre BourquinStuart H Orkin
Jul 18, 2006·Cancer Cell·Denise K WaltersBrian J Druker

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Citations

Nov 10, 2012·Leukemia·C BohnstedtUNKNOWN Nordic Society of Pediatric Hematology and Oncology (NOPHO)
Nov 25, 2011·European Journal of Pediatrics·Annelyse Bruwier, Christophe F Chantrain
Aug 4, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Meng-Ju LiDong-Tsamn Lin
Mar 31, 2012·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Christina Kwok-OleksyMarc K Wallack
Dec 1, 2010·Surgical Pathology Clinics·Mihaela Onciu
Aug 31, 2010·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Thomas KlonischSabine Mai
Oct 29, 2010·Developmental Disabilities Research Reviews·Abraham J ValkenburgDick Tibboel
Feb 15, 2015·Indian Journal of Pediatrics·Rachna Seth, Amitabh Singh
Aug 4, 2012·Pediatric Hematology and Oncology·Benjamin GroßJan-Henning Klusmann
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Michel ZwaanGertjan J L Kaspers
Jan 18, 2018·Expert Review of Anticancer Therapy·Kim KleinGertjan J L Kaspers
Apr 20, 2017·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Martin CernanZuzana Pikalova

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