Jun 1, 1978

Acute leukopenia during topical burn therapy with silver sulfadiazine

American Journal of Surgery
F JarrettR Demling

Abstract

Leukopenia, with a mean white blood cell count of 2,680/mm3, was observed in nine patients with thermal injury early in the course of topical treatment with silver sulfadiazine. All manifested absolute neutropenia with a concomitant increase in immature band forms in the peripheral blood smear. The leukocyte counts returned to within normal limits within 48 to 72 hours of discontinuation of silver sulfadiazine therapy in four patients, and also did so in five patients in whom silver sulfadiazine therapy was continued. Leukopenia secondary to silver sulfadiazine application is currently believed to be an innocuous, self-limited phenomenon.

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Citations

Mentioned in this Paper

SSD
Neutropenia
Acute Disease
Administration, Topical
Leukopenia
Teens
Burn Injury

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