Abstract
Up to now, limited cases with acute liver failure caused by traditional Chinese medicine have been reported, and thus this topic has been scarcely discussed. This study aims to report such cases from China. A retrospective study. Clinical investigation among seven tertiary hospitals in different areas of China. From January 2007 to December 2012, patients with acute liver failure induced by traditional Chinese medicinal herbs were included. None. A total of 30 patients were finally identified, including six men and 24 women. The average age was 39.7 years. The median period from initial symptoms to the development of hepatic encephalopathy was 13 days. Nine patients (30%) had accepted herbal therapies due to their skin disorders before the onset of acute liver failure. Eighteen patients (60%) eventually died, 10 of whom died of heavy bleeding. No patients received liver transplantation. The model of safety monitoring for traditional Chinese materia medica should be established. For those critically ill patients with herb-induced acute liver failure, coagulopathy is a vital problem in critical care. Additionally, the rate of liver transplantation for acute liver failure in China needs to be improved.
References
Mar 10, 2000·Complementary Therapies in Medicine·D MelchartW Weidenhammer
May 2, 2002·European Journal of Gastroenterology & Hepatology·C A McRaeM F Bassendine
Apr 17, 2008·Journal of General Internal Medicine·Stephen Bent
Aug 23, 2008·Journal of Gastroenterology and Hepatology·Chang-Hsing LeePau-Chung Chen
Aug 13, 2011·Clinical and Experimental Pharmacology & Physiology·Kwong-Fai WongJohn M Luk
Mar 27, 2012·Seminars in Respiratory and Critical Care Medicine·William M Lee
Apr 10, 2012·Best Practice & Research. Clinical Gastroenterology·William M Lee
Nov 6, 2012·Alimentary Pharmacology & Therapeutics·C Bunchorntavakul, K R Reddy
Mar 21, 2013·European Journal of Gastroenterology & Hepatology·Yuan ZhouHong Guo
Citations
Mar 19, 2014·Critical Care Medicine·Alan David Kaye
May 16, 2014·Intensive Care Medicine·Gavin M Joynt, Wong Wai Tat
Sep 24, 2015·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Jianqing RuanGe Lin
Feb 15, 2015·Archives of Toxicology·Felix Stickel, Daniel Shouval
Jan 29, 2016·International Journal of Biological Macromolecules·Bing HanJin Pei
Jun 9, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Pan ZhaoUNKNOWN Acute Liver Failure Study Team (ALFST)
Jan 6, 2017·Clinical Transplantation·Narendra Singh ChoudharyArvinder S Soin
Jul 12, 2016·Medicine·Pan ZhaoLilong Yan
Jul 5, 2019·Expert Review of Clinical Pharmacology·Carlotta RiebensahmGilles Wandeler
Aug 9, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Erik W Baars, Harald J Hamre
Oct 15, 2019·Journal of Clinical and Translational Hepatology·Cyriac Abby PhilipsDeepak Madhu
Dec 21, 2019·World Journal of Gastroenterology : WJG·Priya Grewal, Jawad Ahmad
Apr 21, 2018·Toxics·Cecilia Nwadiuto Amadi, Orish Ebere Orisakwe
Dec 2, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Kok-Ann GweeXu-Dong Tang
Dec 17, 2014·Gastroenterology·Leonard B SeeffGuqi Wang