Acute liver failure in Cuban children.

MEDICC Review
César E SilverioOramis Sosa

Abstract

Acute liver failure is rare in pediatric patients and is one of the most challenging medical emergencies due to its prognostic and therapeutic implications. The best scientific evidence worldwide comes from multicenter studies in developed countries. In Cuba, there are no prior studies of this disorder in children. Describe the main clinical features of Cuban children treated at a national referral center for acute liver failure, as defined by recognized diagnostic criteria for pediatric patients. A case series study was conducted comprising patients diagnosed with acute liver failure treated from 2005 to 2011 in the hepatology and liver transplant service at Havana's William Soler University Children's Hospital. Variables were age group, etiology of acute liver failure, grade of hepatic encephalopathy, blood chemistry variables, and clinical outcome (whether or not spontaneous recovery of liver function occurred). Associations between variables were assessed using contingency tables, and case fatality was calculated, as well as relative risk with its 95% confidence interval. The Mann-Whitney U test was used to compare means of laboratory test results. Median age of the 31 patients studied (14 boys and 17 girls) was 24 months (...Continue Reading

Citations

Sep 2, 2020·Pediatric Transplantation·Eduard K BruckmannJean F Botha
Jul 25, 2019·Revista da Associação Médica Brasileira·José Colleti JuniorWerther Brunow de Carvalho
Jul 4, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Guofeng DingHui Li
Jan 4, 2017·Journal of Pediatric Gastroenterology and Nutrition·Vikrant SoodShiv Kumar Sarin
Jan 24, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Seema AlamDinesh Rawat

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