Acute liver failure requiring transplantation caused by ulipristal acetate.

Clinics and Research in Hepatology and Gastroenterology
Lucy MeunierHillaire-Buys Dominique

Abstract

Ulipristal has recently been suspected to be hepatotoxic by the European Medicines Agency but the evidence base for hepatotoxicity is sparse. This is a brief formal report of a patient administered ulipristal for 6-8 weeks and who developed acute liver failure leading to liver transplantation. The explanted liver showed extensive hepatocyte necrosis and inflammation compatible with drug-induced liver injury and cirrhosis. The usual causes of acute hepatitis and cirrhosis were eliminated. There were no other potential causative drugs. This case suggests that ulipristal may cause acute hepatitis, with pre-existing cirrhosis probably contributing to the severity of liver injury observed in this case. Ulipristal prescribers must remain vigilant and monitor liver function in their patients.

References

Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J F RobertsonS Thorpe
Jun 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J FontanaJay H Hoofnagle
Feb 3, 2012·The New England Journal of Medicine·Jacques DonnezUNKNOWN PEARL I Study Group
Apr 5, 2013·Journal of Clinical Pharmacy and Therapeutics·O PohlJ-P Gotteland
Jun 5, 2016·Mayo Clinic Proceedings·Pelin BaturPetra M Casey
Dec 19, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Katalina Funke, Don C Rockey
May 28, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Mohamed GhonimAshraf Nabhan
May 30, 2019·The Journal of Obstetrics and Gynaecology Research·Marie-Madeleine DolmansLatifa Fellah
Jun 27, 2019·Gastroenterology Research·Ishani ShahKeng-Yu Chuang

❮ Previous
Next ❯

Citations

May 16, 2020·Climacteric : the Journal of the International Menopause Society·S G VitaleS Cianci
May 20, 2020·Journal of Clinical Medicine·Michał CiebieraAyman Al-Hendy
Aug 5, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Milo GattiEmanuel Raschi
Oct 10, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Einar S Björnsson
Mar 9, 2021·Expert Review of Clinical Pharmacology·Mohamed AliAyman Al Hendy
Apr 3, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Andrea TinelliGaetano Panese
Jun 11, 2021·Expert Review of Molecular Diagnostics·Ana SalasTeresa A Almeida
Jun 30, 2021·Basic & Clinical Pharmacology & Toxicology·Ricardo Jorge Dinis-Oliveira, Duarte Nuno Vieira
Sep 18, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Joseph William ClintonJames H Lewis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here