Acute low-level alcohol consumption reduces phase locking of event-related oscillations in rodents

Behavioural Brain Research
Leslie R AmodeoC L Ehlers

Abstract

Event-related oscillations (EROs) are rhythmic changes that are evoked by a sensory and/or cognitive stimulus that can influence the dynamics of the EEG. EROs are defined by the decomposition of the EEG signal into magnitude (energy) and phase information and can be elicited in both humans and animals. EROs have been linked to several relevant genes associated with ethanol dependence phenotypes in humans and are altered in selectively bred alcohol-preferring rats. However, pharmacological studies are only beginning to emerge investigating the impact low intoxicating doses of ethanol can have on event-related neural oscillations. The main goal of this study was to investigate the effects of low levels of voluntary consumption of ethanol, in rats, on phase locking of EROs in order to give further insight into the acute intoxicating effects of ethanol on the brain. To this end, we allow rats to self-administer unsweetened 20% ethanol over 15 intermittent sessions. This method results in a stable low-dose consumption of ethanol. Using an auditory event-related potential "oddball" paradigm, we investigated the effects of alcohol on the phase variability of EROs from electrodes implanted into the frontal cortex, dorsal hippocampus, a...Continue Reading

References

Jan 1, 1980·Journal of Biomedical Engineering·E BaşarP Ungan
Aug 3, 1999·Neuroscience·C L EhlersC B Nemeroff
Jul 20, 2002·Trends in Neurosciences·Scott Makeig
Mar 17, 2006·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Henri Begleiter, Bernice Porjesz
May 2, 2009·Journal of Neuroscience Methods·Cindy L Ehlers, Jose R Criado
Mar 14, 2012·Brain Research·Cindy L EhlersJames Havstad
Dec 3, 2013·Alcohol·Leandro F Vendruscolo, Amanda J Roberts
Oct 14, 2014·Handbook of Clinical Neurology·Madhavi Rangaswamy, Bernice Porjesz
Jul 8, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Cindy L EhlersJames Havstad

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Citations

May 4, 2018·CNS Neuroscience & Therapeutics·Francisco E Olucha-BordonauAndrew L Gundlach

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