Acute lung injury following an esophagectomy for esophageal cancer, with special reference to the clinical factors and cytokine levels of peripheral blood and pleural drainage fluid

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
M MoritaY Maehara

Abstract

Acute lung injury (ALI) is one of most serious complications to occur after an esophagectomy for esophageal cancer. However, the pathogenesis of ALI is still unclear. The cytokine levels of pleural drainage fluid as well as peripheral blood were measured in 27 patients who had undergone an extended radical esophagectomy. Both the clinical factors and cytokine levels were compared between 11 patients with (group I) and 16 without ALI (group II). ALI occurred more frequently in patients who underwent colon interposition than in those who received a gastric tube reconstruction (86%vs 25%, P = 0.009). The operation time of group I was significantly longer than that of group II. A logistic regression analysis revealed colon interposition to be an independent factor associated with the ALI (P < 0.05). Postoperative anastomotic leakage and systemic inflammatory response syndrome (SIRS) occurred more frequently in group I than in group II (P < 0.01). Both the serum interleukin-6 (IL-6) and IL-8 levels of group I were significantly higher than those of group II. IL-1beta and tumor necrosis factor-alpha were undetectable in the peripheral blood, whereas they were detectable in the pleural effusion. The IL-1beta of pleural effusion was hi...Continue Reading

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Citations

Sep 25, 2015·The Journal of Medical Investigation : JMI·Mitsuhiro YasudaYoshihiko Maehara
Apr 5, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maryam DerogarPernilla Lagergren
Mar 31, 2012·Acta Cirúrgica Brasileira·Renata Cristiane Gennari BianchiNelson Adami Andreollo
Apr 1, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M KobayashiA Takagane
Aug 21, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R TakahataK Hase
Oct 21, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P R BoshierG B Hanna
Mar 17, 2011·Annals of Surgical Oncology·Masaru MoritaYoshihiko Maehara
Jan 13, 2015·Annals of Surgical Oncology·Akihiko OkamuraYuko Kitagawa
May 12, 2016·Experimental and Therapeutic Medicine·Lijun WangZhanggang Xue
Oct 16, 2019·Surgery Today·Dimitrios SchizasTheodoros Liakakos
Mar 8, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H SaekiY Maehara

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