Acute lung injury induced by Staphylococcal enterotoxin B: disruption of terminal vessels as a mechanism of induction of vascular leak.

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Ali Imran SaeedMitzi Nagarkatti

Abstract

The current hypothesis of alveolar capillary membrane dysfunction fails to completely explain the severe and persistent leak of protein-rich fluid into the pulmonary interstitium, seen in the exudative phase of acute lung injury (ALI). The presence of intact red blood cells in the pulmonary interstitium may suggest mechanical failure of pulmonary arterioles and venules. These studies involved the pathological and ultrastructural evaluation of the pulmonary vasculature in Staphylococcal enterotoxin B (SEB)-induced ALI. Administration of SEB resulted in a significant increase in the protein concentration of bronchoalveolar lavage fluid and vascular leak in SEB-exposed mice compared to vehicle-treated mice. In vivo imaging of mice demonstrated the pulmonary edema and leakage in the lungs of SEB-administered mice. The histopathological studies showed intense clustering of inflammatory cells around the alveolar capillaries with subtle changes in architecture. Electron microscopy studies further confirmed the diffuse damage and disruption in the muscularis layer of the terminal vessels. Cell death in the endothelial cells of the terminal vessels was confirmed with TUNEL staining. In this study, we demonstrated that in addition to fai...Continue Reading

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Citations

Jan 8, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Roshni RaoMitzi Nagarkatti
Mar 8, 2018·Journal of Cellular and Molecular Medicine·Hasan AlghetaaPrakash Nagarkatti
May 6, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Julia SvedovaAnthony T Vella
Mar 17, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hasan AlghetaaPrakash Nagarkatti

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