Acute lung injury: significance, treatment and outcome

Current Opinion in Anaesthesiology
Gilman B Allen, Polly E Parsons

Abstract

This paper aims to provide a condensed review of the most essential and current research findings in the field of acute lung injury over the past year. We review the most recent important findings in both laboratory-based and clinical research in the field of acute lung injury. Significant advances have been made in the past year with respect to our understanding of the pathogenesis of acute lung injury, and how key pathological events relate to prognosis, outcomes, and the promise of new potential therapeutic interventions. In particular, significant advances have been made in our understanding of the prognostic roles of neutrophil recruitment and clearance, fibrinogenesis, inflammatory cytokines, alveolar fluid clearance, and endothelial injury and activation. Paramount studies have provided greater skepticism over the efficacy of prone positioning and the currently available surfactant replacement therapies. In addition, new research has fostered an improved appreciation of the long-term sequelae of acute lung injury. Recent advances in our understanding of the pathogenesis of acute lung injury have provided the promise of exciting potential interventions to modify intravascular and extravascular fibrinogenesis, neutrophil a...Continue Reading

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Citations

Oct 5, 2007·Microbes and Infection·Shang-Chen HsiehHsin-Chih Lai
Aug 26, 2016·Clinical and Experimental Pharmacology & Physiology·Guang-Gang LiZhen-Dong Zheng
Nov 10, 2006·Current Opinion in Anaesthesiology·Ron Dueck
Aug 19, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Giuseppe A MarraroAlessandro Monici Preti Piero
Nov 10, 2006·Current Opinion in Anaesthesiology

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