Acute lung rejection after heart-lung transplantation: correlation of findings on chest radiographs with lung biopsy results

AJR. American Journal of Roentgenology
C J BerginV A Starnes

Abstract

This retrospective study was performed to determine if the chest radiograph could serve as a predictor for acute lung rejection in heart-lung transplantation patients. The findings on chest radiographs were correlated with the results of transbronchial biopsies in 16 heart-lung transplantation patients. The chest radiographs immediately preceding 83 biopsies were evaluated for a variety of findings. The histopathologic results of the lung biopsies were divided into five categories: (1) acute lung rejection (n = 25); (2) suggestive, but not diagnostic, of acute lung rejection (n = 8); (3) nonspecific (n = 26); (4) infection (n = 17); and (5) normal lung (n = 9). Biopsies from two patients showed both acute lung rejection and cytomegalovirus infection and were included in both categories. These histopathologic results were then correlated with the radiologic observations. We found that the combination of septal lines and new or increasing pleural effusions, without concomitant increase in cardiac size or vascular pedicle width, or evidence of vascular redistribution, indicated acute lung rejection with a sensitivity of 68% (17/25), specificity of 90% (52/58), and overall accuracy of 83% (69/83). We conclude that the chest radiogr...Continue Reading

Citations

Apr 16, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·David ShitritMordechai R Kramer
Mar 3, 2009·AJR. American Journal of Roentgenology·Yuen Li NgGordon Weisbrod
Feb 7, 2001·Journal of Computer Assisted Tomography·J P KoT C McLoud
Jan 1, 1997·Scandinavian Cardiovascular Journal : SCJ·T IkonenA L Harjula
Apr 1, 1997·Chest·M A JudsonS A Sahn
May 1, 1993·Chest·E P Trulock
Feb 21, 2016·Radiologic Clinics of North America·Clinton JokerstTan-Lucien H Mohammed
Jul 29, 2010·Mayo Clinic Proceedings·Chakradhar VenkataBekele Afessa
Nov 3, 2005·Clinics in Chest Medicine·Rosita M Shah, Wallace Miller
Nov 3, 2005·Clinics in Chest Medicine·Vivek N Ahya, Steven M Kawut
Jun 1, 1997·Clinics in Chest Medicine·M B King-Biggs
Feb 15, 2014·Diagnostic and Interventional Imaging·C HemmertC Roy
Feb 3, 2016·Chest·Vickram TejwaniAtul C Mehta
May 5, 2006·Current Opinion in Critical Care·Russell R Miller, E Wesley Ely
Apr 17, 2002·Journal of Thoracic Imaging·Jannette Collins
Feb 18, 1998·Radiologic Clinics of North America·R M SloneR D Yusen
Dec 10, 1999·Clinics in Chest Medicine·J A Shepard
Apr 26, 2007·Journal de radiologie·J IsnardB Dupas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.