Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus

Lupus
M GokceM Cetin

Abstract

Haematological involvement of systemic lupus erythematosus (SLE) - which ranges from the well-described haemolytic anaemia to macrophage activation syndrome - has a large impact on both morbidity and mortality. On the other hand, association between haematological malignities and SLE - in terms of pathophysiology and molecular genetics - is an obscure entity which has not been clarified evidently to date. Herein, we present a six-year-old female with the diagnosis of SLE who developed acute lymphoblastic leukaemia following a period of myelodysplasia. It could possibly be coincidental; however, persistent cytopenia, prominent dysplasia on bone marrow smears and azathioprine treatment may be considered as possible triggers for the development of leukaemia in the present case.

References

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Citations

Nov 26, 2013·Arthritis Research & Therapy·Sasha BernatskyRosalind Ramsey-Goldman
Aug 3, 2017·The Journal of Rheumatology·Sasha BernatskyRosalind Ramsey-Goldman
May 15, 2020·Current Rheumatology Reports·Ummusen Kaya Akca, Nuray Aktay Ayaz
Dec 12, 2017·Best Practice & Research. Clinical Rheumatology·May Y ChoiAnn E Clarke

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Methods Mentioned

BETA
biopsy
light microscopy
flow cytometry
bone marrow aspiration
MDS

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