Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation

Pediatric Blood & Cancer
Hiroyuki MomotaSoichiro Shibui

Abstract

We present a case of a 12-year-old female with a germline TP53 mutation who presented with anaplastic astrocytoma and subsequent acute lymphoblastic leukemia (ALL) 13 months after starting treatment with temozolomide (TMZ). The patient had no family history of malignancy except her grand father and his siblings. Although alkylating agents such as TMZ are known to induce secondary hematologic malignancy, only several cases of treatment-related acute leukemia have been reported after TMZ-alone chemotherapy for malignant gliomas. We demonstrate a rare case of TMZ-related ALL in a child with glioma possibly associated with a germline TP53 mutation.

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Citations

Aug 26, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Canan AkyüzMünevver Büyükpamukçu
Mar 23, 2013·Neuro-oncology·Hiroyuki MomotaSoichiro Shibui
Aug 2, 2012·Anti-cancer Drugs·Sanjay DixitMohan Hingorani
Jan 7, 2014·PloS One·Hui-Jen TsaiJeffrey S Chang
Dec 3, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kuan-Nien ChouPing-Ying Chang
Jul 8, 2015·Leukemia & Lymphoma·T Cassou-MounatM Puyade
Apr 27, 2011·British Journal of Haematology·Mizuki OguraMineo Kurokawa
Jul 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jana HofRenate Kirschner-Schwabe
Aug 25, 2017·Nature Reviews. Cancer·Megan E McNerneyMichelle M Le Beau
Dec 16, 2011·The Journal of Clinical Endocrinology and Metabolism·Leonie J M HerrmannStefanie Hahner

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