Acute lymphoblastic leukemia presenting with lactic acidosis and renal tubular dysfunction

Journal of Pediatric Hematology/oncology
Mohammed Hayek, Ashok Srinivasan

Abstract

Acute lymphoblastic leukemia (ALL) in children can rarely present with severe lactic acidosis in the absence of a high white blood cell count or other complications. Renal tubular dysfunction with hypercalciuria and hypocalcemia in the absence of pre-existing renal disease or concurrent medications has not been described at presentation in childhood ALL. The authors describe a 7-year-old boy with ALL presenting with severe lactic acidosis and renal tubular dysfunction, both of which were refractory to conventional management and resolved rapidly with appropriate chemotherapy.

References

Sep 1, 1966·The American Journal of Medicine·G W Jordan
May 1, 1983·European Journal of Cancer & Clinical Oncology·J P SculierJ Klastersky
Dec 10, 1999·American Journal of Hematology·H J MilionisM S Elisaf

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Citations

Feb 2, 2008·Pediatric Radiology·Melissa A HilmesPeter J Strouse
Aug 3, 2011·Radiologic Clinics of North America·R Paul GuillermanBruce R Parker
Sep 27, 2012·Clinical Lymphoma, Myeloma & Leukemia·Patrick TangMojtaba Akhtari
Jul 14, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Kamal Kant SahuSubhash Chander Varma
Sep 5, 2018·Pediatric Emergency Care·Abigail M SchuhNeil G Uspal
Mar 9, 2018·Case Reports in Oncology·Tatsunori YoshidaHiroyuki Suzuki

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