Acute lymphoblastic leukemia subtypes in Israel: the Sheba medical center experience

Leukemia Research
B RamotS Orgad

Abstract

During the period from 1978 to 1981, 52 patients with ALL were diagnosed and treated at the Chaim Sheba Medical Center. Using standard cell markers to subtype the blasts, 49 of the patients could be classified: 16 were found to be T-cell ALL, 10 common ALL, five null ALL, four pre-B and 14 were partially characterized as non-B, non-T. Analysis of the series revealed two distinctive features: high prevalence (30%) of T-cell ALL among both Jews and Arabs and a high proportion, two-thirds, of high risk patients due to high initial WBC counts, unfavourable age or T-cell characteristics. The minimal incidence of ALL among the Gaza Strip Arab children during the study period is 4:100,000, which is close to the incidence in the Western world. During previous years the leukemia incidence in the Gaza Strip was very low while the most common lymphatic malignancies were Burkitt tumor and other non-Hodgkin lymphomas.

References

Jan 29, 1976·The New England Journal of Medicine·I TsukimotoB C Lampkin
Apr 20, 1978·The New England Journal of Medicine·L B VoglerM D Cooper
Jun 14, 1979·The New England Journal of Medicine·G H ReamanD G Poplack
Feb 11, 1975·The Journal of Pediatrics·J L Young, R W Miller
Jan 20, 1973·Lancet·J WybranH H Fudenberg
Jan 1, 1981·Medical and Pediatric Oncology·I Ben-BassatB Ramot
Jan 1, 1981·Medical and Pediatric Oncology·S C Steinhorn, M H Myers
Jun 1, 1980·Pediatric Research·M F Heath, W Jacobson

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Citations

Jan 1, 1985·Leukemia Research·D M KamatJ S Nadkarni
Jan 1, 1983·Medical and Pediatric Oncology·G KendeB Ramot

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